| Gene Symbol |
RAB11A
|
| Entrez Gene |
8766
|
| Alt Symbol |
YL8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB11A, member RAS oncogene family
|
| Other Description |
RAB 11A, member oncogene family|rab-11|ras-related protein Rab-11A
|
| Swissprots |
B4DT13 Q9JLX1 B2R4B6 Q5TZN9 P24410 P62491
|
| Accessions |
EAW77752 EAW77753 P62491 AF000231 AAC32887 AF498946 AAM21094 AK054930 AK297549 BAG59943 AK298961 BAG61057 AK300008 BAG61825 AK311770 BAG34713 BC013348 AAH13348 BC047114 BI550703 BT020151 AAV38953 BT020154 AAV38956 CR407669 CAG28597 CR536493 CAG38732 DC300743 DQ893054 ABM83980 DQ896303 ABM87302 X53143 CAA37300 X56740 CAA40064 NM_001206836 NP_001193765 NM_004663 NP_004654
|
| Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane.
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis.
|
| Top Pathways |
Endocytosis, Vasopressin-regulated water reabsorption, Pancreatic secretion, Endocrine and other factor-regulated calcium reabsorption
|
![Western Blot: Rab11A Overexpression Lysate (Adult Normal) [NBL1-15038] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Rab11A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8773_Rab11A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15038-img0002.jpg)