RAB11A

Gene Symbol	RAB11A
Entrez Gene	8766
Alt Symbol	YL8
Species	Human
Gene Type	protein-coding
Description	RAB11A, member RAS oncogene family
Other Description	RAB 11A, member oncogene family|rab-11|ras-related protein Rab-11A
Swissprots	B4DT13 Q9JLX1 B2R4B6 Q5TZN9 P24410 P62491
Accessions	EAW77752 EAW77753 P62491 AF000231 AAC32887 AF498946 AAM21094 AK054930 AK297549 BAG59943 AK298961 BAG61057 AK300008 BAG61825 AK311770 BAG34713 BC013348 AAH13348 BC047114 BI550703 BT020151 AAV38953 BT020154 AAV38956 CR407669 CAG28597 CR536493 CAG38732 DC300743 DQ893054 ABM83980 DQ896303 ABM87302 X53143 CAA37300 X56740 CAA40064 NM_001206836 NP_001193765 NM_004663 NP_004654
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane.
Subcellular Location	Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis.
Top Pathways	Endocytosis, Vasopressin-regulated water reabsorption, Pancreatic secretion, Endocrine and other factor-regulated calcium reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Rab11A full length protein - ab90041 from Abcam Category Protein Prices $239.00 Sizes 50 µg Source E. coli Species Human

Human Rab11A (mutated Q70 L) protein fragment - ab176667 from Abcam Category Protein Source E. coli Species Human

Human Rab11A full length protein - ab117177 from Abcam Category Protein Source E. coli Species Human

Human Rab11A protein fragment - ab176681 from Abcam Category Protein Source E. coli Species Human

Rab11A peptide - ab45475 from Abcam Category Peptide

RAB11A Antibody Blocking Peptide - LS-E3355 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB11A Antibody Blocking Peptide - LS-E25407 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB11A Antibody Blocking Peptide - LS-E23248 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB11A Antibody Blocking Peptide - LS-E23249 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Rab11A Recombinant Protein - H00008766-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Rab11A Protein - NBP1-44381 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

RAB11A-Antibody-Center-Blocking-Peptide - BP14530c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Rab11A blocking peptide - GTX89906-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

RAB11A Protein (OPPA02350) - OPPA02350 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human RAB11A protein - orb246422 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human RAB11A protein - orb81295 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

Goat anti RAB11A antibody Immunizing peptide - orb17351 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

RAB11A protein (His tag) - 80R-1321 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

RAB11A Peptide - AC21-0235-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RAB11A / RAB11 (1-213, His-tag) - AR09467PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

RAB11A / RAB11 (1-213, His-tag) - AR09467PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

RAB11A / RAB11 - H00008766-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

RAB11A / RAB11 control peptide - SP5288CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

RAB11A, Member RAS Oncogene Family, Human Recombinant - 228-13267-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human RAB11A, Member RAS Oncogene Family - 228-13267-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

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