NSMCE1

Gene Symbol	NSMCE1
Entrez Gene	197370
Alt Symbol	NSE1
Species	Human
Gene Type	protein-coding
Description	non-SMC element 1 homolog (S. cerevisiae)
Other Description	non-structural maintenance of chromosomes element 1 homolog
Swissprots	Q8WV22 Q9P045 Q9P049 D3DWF6
Accessions	EAW55754 EAW55755 EAW55756 EAW55757 EAW55758 Q8WV22 AF161451 AAF29011 AF161455 AAF29015 AK056795 AK315674 BAG38039 BC018938 AAH18938 BU685363 DB463393 XM_006721023 XP_006721086 XM_011545761 XP_011544063 XM_011545762 XP_011544064 XM_011545763 XP_011544065 NM_145080 NP_659547
Function	Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269\|PubMed:18086888, ECO:0000269\|PubMed:20864041}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:18086888}. Chromosome, telomere {ECO:0000305\|PubMed:18086888}.

NSE1 (D-2) - sc-376585 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

NSE1 (D-2): sc-376585. Western blot analysis of NSE1 expression in Hep G2 (A) and PC-3 (B) nuclear extracts.

NSE1 (G-12) - sc-132007 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

NSE1 (H-178) - sc-292097 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

NSE1 (H-178): sc-292097. Western blot analysis of NSE1 expression in HL-60 whole cell lysate.

NSE1 (P-12) - sc-132009 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-NSMCE1 antibody - ab96815 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of NSMCE1 in paraffin- embedded SW480 xenograft, using ab96815 antibody at a 1/500 dilution.

Anti-NSMCE1 antibody - ab168578 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-NSMCE1 antibody (ab168578) at 1 µg/mlLane 1 : NSMCE1-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG developed using the ECL technique

Anti-NSMCE1 antibody - ab66956 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NSMCE1 antibody (ab66956) at 2.5 µg/ml + HepG2 cell lysate at 10 µg with 5% skim milk / PBS bufferSecondaryHRP conjugated anti-Rabbit IgG at 50,000 - 100,000 dilution

Anti-NSMCE1 antibody [EPR9103(B)] - ab139689 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR9103(B)

Immunohistochemical analysis of paraffin-embedded Human cervical carcinoma tissue labelling NSMCE1 with ab139689 at 1/50 dilution.

Anti-NSMCE1 antibody - C-terminal - ab173887 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NSMCE1 antibody - C-terminal (ab173887) at 1/100 dilution + A375 cell lysate at 35 µg

Anti-NSMCE1 Antibody (aa222-249, AP) - LS-C216095 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NSMCE1 Antibody (aa222-249, APC) - LS-C216097 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NSMCE1 Antibody (aa222-249, Biotin) - LS-C216098 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NSMCE1 Antibody (aa81-130) - LS-C31999 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NSMCE1 Antibody (aa222-249, FITC) - LS-C216099 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NSMCE1 Antibody (aa222-249, Azide-free, HRP) - LS-C216100 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NSMCE1 Antibody (aa222-249, PE) - LS-C216101 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NSMCE1 Antibody (aa221-249) - LS-C323463 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NSMCE1 Antibody (aa143-192) - LS-C116235 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

NSMCE1 antibody LS-C116235 Western blot of HepG2 cell lysate.

Anti-NSMCE1 Antibody (aa222-249) - LS-C158426 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

NSMCE1 Antibody western blot of A375 cell line lysates (35 ug/lane). The NSMCE1 Antibody detected the NSMCE1 protein (arrow).

Anti-NSMCE1 Antibody (aa1-266) - LS-C185863 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded SW480 xenograft using NSMCE1 antibody at 1:500 dilution.

NSMCE1 Antibody - NBP1-92201 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: NSMCE1 Antibody [NBP1-92201] - Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm & vesicles.

NSMCE1 Antibody - NBP1-92200 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: NSMCE1 Antibody [NBP1-92200] - Staining of human kidney shows strong cytoplasmic, membranous and extracellular positivity in cells in tubules.

NSMCE1 Antibody - NBP1-32527 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: NSMCE1 Antibody [NBP1-32527] - Sample(30 ug whole cell lysate)A:Raji 12% SDS PAGE, antibody diluted at 1:2000.

NSMCE1 Antibody - H00197370-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-NSMCE1 antibody produced in mouse - SAB1408968 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Anti-NSMCE1: <B>Cat. No. SAB1408968</B>: Antibody concentration: 10 μg/mL using HeLa cell.

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