Gene Symbol | NSMCE1 |
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Entrez Gene | 197370 |
Alt Symbol | NSE1 |
Species | Human |
Gene Type | protein-coding |
Description | non-SMC element 1 homolog (S. cerevisiae) |
Other Description | non-structural maintenance of chromosomes element 1 homolog |
Swissprots | Q8WV22 Q9P045 Q9P049 D3DWF6 |
Accessions | EAW55754 EAW55755 EAW55756 EAW55757 EAW55758 Q8WV22 AF161451 AAF29011 AF161455 AAF29015 AK056795 AK315674 BAG38039 BC018938 AAH18938 BU685363 DB463393 XM_006721023 XP_006721086 XM_011545761 XP_011544063 XM_011545762 XP_011544064 XM_011545763 XP_011544065 NM_145080 NP_659547 |
Function | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888, ECO:0000269|PubMed:20864041}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}. |
NSE1 CRISPR/Cas9 KO Plasmid (h) - sc-402593 from Santa Cruz Biotechnology
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NSE1 HDR Plasmid (h) - sc-402593-HDR from Santa Cruz Biotechnology
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NSE1 Double Nickase Plasmid (h) - sc-402593-NIC from Santa Cruz Biotechnology
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NSE1 Double Nickase Plasmid (h2) - sc-402593-NIC-2 from Santa Cruz Biotechnology
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NSE1 CRISPR Activation Plasmid (h) - sc-402593-ACT from Santa Cruz Biotechnology
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NSE1 CRISPR Activation Plasmid (h2) - sc-402593-ACT-2 from Santa Cruz Biotechnology
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NSE1 Lentiviral Activation Particles (h) - sc-402593-LAC from Santa Cruz Biotechnology
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NSE1 Lentiviral Activation Particles (h2) - sc-402593-LAC-2 from Santa Cruz Biotechnology
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NSE1 siRNA (h) - sc-93235 from Santa Cruz Biotechnology
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NSE1 shRNA Plasmid (h) - sc-93235-SH from Santa Cruz Biotechnology
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NSE1 shRNA (h) Lentiviral Particles - sc-93235-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU145991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15535 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15535 from Sigma-Aldrich
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NSMCE1 siRNA (Human) - CRJ6204 from Cohesion Biosciences
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NSMCE1 RNAi - H00197370-R01 from Novus Biologicals
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shRNA set against Human NSMCE1 (NM_145080.3) - SHH355392 from Creative biogene
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Human NSMCE1 siRNA - orb276705 from Biorbyt
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NSMCE1 shRNA Plasmid (Human) - CHJ6204 from Cohesion Biosciences
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NSMCE1 miRNA 3'UTR clone - MiUTR1H-06937 from Creative biogene
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