Gene Symbol | TIMP2 |
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Entrez Gene | 7077 |
Alt Symbol | CSC-21K, DDC8 |
Species | Human |
Gene Type | protein-coding |
Description | TIMP metallopeptidase inhibitor 2 |
Other Description | metalloproteinase inhibitor 2|tissue inhibitor of metalloproteinases 2 |
Swissprots | Q16121 Q9UDF7 Q93006 P16035 |
Accessions | AAC50729 AAD14025 CAR95106 CAS92764 EAW89538 EAW89539 EAW89540 EAW89541 P16035 AK294290 BAG57573 AL110197 AL713764 BC010410 BC039613 BC040039 BC040445 BC052605 AAH52605 BC071586 AAH71586 HQ448393 ADQ32873 J05593 AAA61186 M32304 AAA59581 S48568 AAB19474 X54533 CAA38400 NM_003255 NP_003246 |
Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. {ECO:0000269|PubMed:11710594, ECO:0000269|PubMed:2554304, ECO:0000269|PubMed:2793861}. |
Subcellular Location | Secreted. |
TIMP-2 CRISPR/Cas9 KO Plasmid (h) - sc-400685 from Santa Cruz Biotechnology
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TIMP-2 HDR Plasmid (h) - sc-400685-HDR from Santa Cruz Biotechnology
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TIMP-2 Double Nickase Plasmid (h) - sc-400685-NIC from Santa Cruz Biotechnology
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TIMP-2 Double Nickase Plasmid (h2) - sc-400685-NIC-2 from Santa Cruz Biotechnology
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TIMP-2 CRISPR Activation Plasmid (h) - sc-400685-ACT from Santa Cruz Biotechnology
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TIMP-2 CRISPR Activation Plasmid (h2) - sc-400685-ACT-2 from Santa Cruz Biotechnology
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TIMP-2 Lentiviral Activation Particles (h) - sc-400685-LAC from Santa Cruz Biotechnology
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TIMP-2 Lentiviral Activation Particles (h2) - sc-400685-LAC-2 from Santa Cruz Biotechnology
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TIMP-2 siRNA (h) - sc-29506 from Santa Cruz Biotechnology
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TIMP-2 shRNA Plasmid (h) - sc-29506-SH from Santa Cruz Biotechnology
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TIMP-2 shRNA (h) Lentiviral Particles - sc-29506-V from Santa Cruz Biotechnology
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TIMP-2 RNAi - H00007077-R02 from Novus Biologicals
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TIMP-2 RNAi - H00007077-R01 from Novus Biologicals
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MISSION® esiRNA - EHU017331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21368 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21368 from Sigma-Aldrich
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TIMP2 siRNA (Human) - CRH4846 from Cohesion Biosciences
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TIMP2 - MBS8228110 from MyBioSource
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shRNA set against Human TIMP2 (NM_003255.4) - SHH427532 from Creative biogene
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shRNA set against Human TIMP2(NM_003255.4) - SHL071766 from Creative biogene
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Human TIMP2 siRNA - orb265348 from Biorbyt
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TIMP2 shRNA Plasmid (Human) - CHH4846 from Cohesion Biosciences
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TIMP2 miRNA 3'UTR clone - MiUTR1H-10417 from Creative biogene
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