| Gene Symbol |
Pitx3
|
| Entrez Gene |
18742
|
| Alt Symbol |
Ptx3, ak
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
paired-like homeodomain transcription factor 3
|
| Other Description |
Pituitary homeobox 3 (Homeobox protein PITX3)|aphakia|homeobox protein PITX3|pituitary homeobox 3
|
| Swissprots |
Q0VB03 O35160
|
| Accessions |
EDL41981 O35160 AB221559 AB971349 BAR42578 AF005772 AAB87380 BC120844 AAI20845 BC137810 AAI37811 XM_006526764 XP_006526827 NM_008852 NP_032878
|
| Function |
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1- mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior len
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138, ECO:0000269|PubMed:17184956}.
|
| Tissue Specificity |
Highly expressed in developing eye lens. Expression is restricted to the substantia nigra and ventral tegmental area in the midbrain. {ECO:0000269|PubMed:15950611, ECO:0000269|PubMed:19007884}.
|