| Gene Symbol | Pitx3 |
|---|---|
| Entrez Gene | 18742 |
| Alt Symbol | Ptx3, ak |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | paired-like homeodomain transcription factor 3 |
| Other Description | Pituitary homeobox 3 (Homeobox protein PITX3)|aphakia|homeobox protein PITX3|pituitary homeobox 3 |
| Swissprots | Q0VB03 O35160 |
| Accessions | EDL41981 O35160 AB221559 AB971349 BAR42578 AF005772 AAB87380 BC120844 AAI20845 BC137810 AAI37811 XM_006526764 XP_006526827 NM_008852 NP_032878 |
| Function | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1- mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior len |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138, ECO:0000269|PubMed:17184956}. |
| Tissue Specificity | Highly expressed in developing eye lens. Expression is restricted to the substantia nigra and ventral tegmental area in the midbrain. {ECO:0000269|PubMed:15950611, ECO:0000269|PubMed:19007884}. |
Pitx3 CRISPR/Cas9 KO Plasmid (m) - sc-422254 from Santa Cruz Biotechnology
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Pitx3 HDR Plasmid (m) - sc-422254-HDR from Santa Cruz Biotechnology
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Pitx3 Double Nickase Plasmid (m) - sc-422254-NIC from Santa Cruz Biotechnology
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Pitx3 Double Nickase Plasmid (m2) - sc-422254-NIC-2 from Santa Cruz Biotechnology
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Pitx3 CRISPR Activation Plasmid (m) - sc-422254-ACT from Santa Cruz Biotechnology
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Pitx3 CRISPR Activation Plasmid (m2) - sc-422254-ACT-2 from Santa Cruz Biotechnology
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Pitx3 Lentiviral Activation Particles (m) - sc-422254-LAC from Santa Cruz Biotechnology
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Pitx3 Lentiviral Activation Particles (m2) - sc-422254-LAC-2 from Santa Cruz Biotechnology
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Pitx3 siRNA (m) - sc-152282 from Santa Cruz Biotechnology
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Pitx3 shRNA Plasmid (m) - sc-152282-SH from Santa Cruz Biotechnology
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Pitx3 shRNA (m) Lentiviral Particles - sc-152282-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN38780 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38780 from Sigma-Aldrich
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PITX3 siRNA (Mouse) - CRM3078 from Cohesion Biosciences
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shRNA set against Mouse PITX3 (NM_008852.4) - SHH376264 from Creative biogene
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shRNA set against Mouse Pitx3(NM_008852.4) - SHR116790 from Creative biogene
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PITX3 shRNA Plasmid (Mouse) - CHM3078 from Cohesion Biosciences
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PITX3 miRNA 3'UTR clone - MiUTR1M-09250 from Creative biogene
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