Pitx3

Gene Symbol	Pitx3
Entrez Gene	18742
Alt Symbol	Ptx3, ak
Species	Mouse
Gene Type	protein-coding
Description	paired-like homeodomain transcription factor 3
Other Description	Pituitary homeobox 3 (Homeobox protein PITX3)|aphakia|homeobox protein PITX3|pituitary homeobox 3
Swissprots	Q0VB03 O35160
Accessions	EDL41981 O35160 AB221559 AB971349 BAR42578 AF005772 AAB87380 BC120844 AAI20845 BC137810 AAI37811 XM_006526764 XP_006526827 NM_008852 NP_032878
Function	Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1- mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior len
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138, ECO:0000269|PubMed:17184956}.
Tissue Specificity	Highly expressed in developing eye lens. Expression is restricted to the substantia nigra and ventral tegmental area in the midbrain. {ECO:0000269|PubMed:15950611, ECO:0000269|PubMed:19007884}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Recombinant Mouse Pituitary homeobox 3 (OPCA00184) - OPCA00184 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Mouse

Recombinant Mouse Pituitary homeobox 3 (OPCA01288) - OPCA01288 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Mouse

Mouse Pitx3 protein - orb244442 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Mouse

Mouse Pitx3 protein - orb245958 from Biorbyt Category Protein Prices $340.00, $629.00, $649.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Mouse

Recombinant mouse Pituitary homeobox 3 - CSB-YP018044MO CSB-BP018044MO CSB-MP018044MO from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Mouse

Recombinant Mouse Pituitary homeobox 3(Pitx3) - CSB-EP018044MO from Cusabio Category Protein Source Yeast Species Mouse

Pituitary homeobox 3 - RPC141003 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Mouse

Pituitary homeobox 3 - RPC141004 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Mouse

Pituitary homeobox 3 , Recombinant Protein - MBS1036049 from MyBioSource Category Protein Prices $185.00, $420.00, $680.00, $1,070.00 Sizes 50 µg (Yeast), 200 µg (Yeast), 500 µg (Yeast), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Mouse PITX3 Protein - PITX3-12851M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Recombinant Mouse Pituitary homeobox 3(Pitx3) - CSB-YP018044MO from Cusabio Category Protein Source Yeast Species Mouse

Recombinant Mouse Pituitary homeobox 3(Pitx3) - CSB-MP018044MO from Cusabio Category Protein Source Yeast Species Mouse

Recombinant Mouse Pituitary homeobox 3(Pitx3) - CSB-BP018044MO from Cusabio Category Protein Source Yeast Species Mouse

Recombinant mouse Pituitary homeobox 3 - AP70636 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Mouse

Recombinant mouse Pituitary homeobox 3 - AP72721 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Mouse

Pituitary homeobox 3, Recombinant Protein - MBS9422439 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Mouse

Pituitary homeobox 3, Recombinant Protein - MBS9420541 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Mouse

Recombinant Mouse Pituitary homeobox 3 (Pitx3) - RPC21819 from Biomatik Category Protein Prices $276.00, $505.00, $2,491.00 Sizes 50 µg, 100 µg, 1 mg Source E.coli Species Mouse

Recombinant Mouse Pituitary homeobox 3 (Pdia2) - RPC24875 from Biomatik Category Protein Prices $275.00, $503.00, $2,499.00 Sizes 50 µg, 100 µg, 1 mg Source Yeast Species Mouse

Recombinant Mouse PITX3 Protein (1-302 aa), His-tagged - PITX3-1484M from Creative Biomart Category Protein Source Yeast Species Mouse

Recombinant Mouse PITX3 Protein (1-302 aa), GST-tagged - PITX3-720M from Creative Biomart Category Protein Source E. coli Species Mouse

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