UPF3A

Gene Symbol	UPF3A
Entrez Gene	65110
Alt Symbol	HUPF3A, RENT3A, UPF3
Species	Human
Gene Type	protein-coding
Description	UPF3 regulator of nonsense transcripts homolog A (yeast)
Other Description	hUpf3|nonsense mRNA reducing factor 3A|regulator of nonsense transcripts 3A|up-frameshift suppressor 3 homolog A
Swissprots	Q5T8C9 A2A366 Q7Z6N3 Q5T8C3 Q86YK1 Q9BZI8 Q9H1J1
Accessions	EAX09247 EAX09248 EAX09249 EAX09250 EAX09251 EAX09252 Q9H1J1 AF318575 AAG60690 AK001069 AK092586 AK097027 BAG53409 AK294545 BAG57751 AK302003 BAG63406 AY013250 AAG48510 BC008694 AAH08694 BC023569 AAH23569 BC047735 BQ008047 XM_005266200 XP_005266257 XM_005266201 XP_005266258 XM_005266202 XP_005266259 XM_006719991 XP_006720054 XM_011534844 XP_011533146 XM_011534845 XP_011533147 XM_011534846 XP_011533148 XM_011534847 XP_011533149 XM_011534848 XP_011533150 XM_011534849 XP_011533151 XM_011534850 XP_011533152 XR_941422 XR_941423 NM_023011 NP_075387 NM_080687 NP_542418
Function	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}.
Subcellular Location	Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
Tissue Specificity	Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord. {ECO:0000269|PubMed:11113196}.
Top Pathways	RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UPF3A / UPF3 Antibody Blocking Peptide - LS-E15040 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UPF3A / UPF3 Antibody Blocking Peptide - LS-E27186 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UPF3A Protein - H00065110-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human UPF3A Protein - H00065110-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

UPF3A-Antibody-Center-Blocking-peptide - BP12579c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UPF3A/RENT3A blocking peptide - GTX88284-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

UPF3A Blocking Peptide - 33R-7719 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UPF3A Peptide - AC21-2006-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UPF3A / RENT3A - H00065110-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UPF3A / RENT3A - H00065110-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UPF3A / RENT3A - H00065110-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

UPF3A / RENT3A - H00065110-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UPF3A / RENT3A - H00065110-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UPF3A Peptide - 42-211P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

UPF3A fusion protein - ag10799 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human UPF3A, His-tagged - UPF3A-31672TH from Creative Biomart Category Protein Source E. coli

Recombinant Human Regulator of nonsense transcripts 3A(UPF3A) - CSB-YP875647HU CSB-EP875647HU CSB-BP875647HU CSB-MP875647HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UPF3A / RENT3A (transcript variant 2) - TP304333 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

UPF3A/RENT3A, Peptide - MBS426546 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Bovine

UPF3A Recombinant Protein Antigen - NBP1-83136PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

UPF3A Peptide, Human - M34GP17107H from Creative Peptides Category Peptide Source Synthetic. Species Human

Regulator of nonsense transcripts 3A (UPF3A), Recombinant Protein - MBS1468667 from MyBioSource Category Protein Prices $1,260.00, $1,260.00, $1,480.00, $1,480.00, $2,055.00, $2,055.00, $2,520.00, $2,520.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

UPF3A Immunizing peptide - orb59709 from Biorbyt Category Peptide

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