ELOVL5

Gene Symbol ELOVL5
Entrez Gene 60481
Alt Symbol HELO1, SCA38, dJ483K16.1
Species Human
Gene Type protein-coding
Description ELOVL fatty acid elongase 5
Other Description 3-keto acyl-CoA synthase ELOVL5|ELOVL FA elongase 5|ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)|elongation of very long chain fatty acids protein 5|fatty acid elongase 1|homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2|spinocerebellar ataxia 38|very-long-chain 3-oxoacyl-CoA synthase 5
Swissprots B4DZJ2 Q9NYP7 Q8NCG4 Q6NXE7 Q9UI22 F6SH78 Q7L2S5 Q59EL3 Q5TGH5
Accessions CAF86084 EAX04413 EAX04414 EAX04415 EAX04416 EAX04417 EAX04418 EAX04419 EAX04420 EAX04421 EAX04422 Q9NYP7 AB209798 BAD93035 AF052129 AF111849 AAF16688 AF231981 AAF70631 AF338241 AAM00193 AK074748 BAC11178 AK074889 BAC11270 AK125098 BAG54141 AK299674 BAG61584 AK302948 BAG64104 AL136939 CAB66873 BC009838 BC017270 AAH17270 BC067123 AAH67123 BC074503 DB143083 DB225467 DC345924 DQ980601 HQ447433 ADQ31919 NM_001242828 NP_001229757 NM_001242830 NP_001229759 NM_001242831 NP_001229760 NM_001301856 NP_001288785 NM_021814 NP_068586
Function Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:10970790, ECO:0000269|PubMed:20937905}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:25065913}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. {ECO:0000269|PubMed:25065913}.
Tissue Specificity Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum. {ECO:0000269|PubMed:10970790, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:25065913}.
Top Pathways Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

ELOVL5 (B-3) - sc-374138 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ELOVL5 (B-3): sc-374138. Western blot analysis of ELOVL5 expression in HeLa whole cell lysate.

ELOVL5 (C-15) - sc-54881 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ELOVL5 (C-15): sc-54881. Western blot analysis of ELOVL5 expression in HeLa (A), MCF7 (B) and MDA-MB-435S (C) whole cell lysates.

ELOVL5 (H-89) - sc-135062 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-ELOVL5 antibody - ab109983 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab109983 at 1/50 dilution staining ELOVL5 in paraffin-embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-ELOVL5 antibody - ab103508 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ELOVL5 antibody (ab103508) at 1/100 dilution + Hela cell line lysates at 35 µg

Anti-HELO1 / ELOVL5 Antibody (C-Terminus) IHC-plus™ - LS-A9855 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ELOVL5 antibody LS-A9855 IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HELO1 / ELOVL5 Antibody (Internal) IHC-plus™ - LS-A8398 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ELOVL5 antibody LS-A8398 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HELO1 / ELOVL5 Antibody (aa240-269, PE) - LS-C234922 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa271-299, AP) - LS-C234923 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa271-299, Biotin) - LS-C234925 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa271-299, APC) - LS-C234924 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa271-299, FITC) - LS-C234926 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa271-299, PE) - LS-C234929 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa240-269) - LS-C167738 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ELOVL5 Antibody western blot of MDA-MB435 cell line lysates (35 ug/lane). The ELOVL5 antibody detected the ELOVL5 protein (arrow).

Anti-HELO1 / ELOVL5 Antibody (N-Terminus) - LS-C81426 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal heart lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-HELO1 / ELOVL5 Antibody (aa240-269, AP) - LS-C246882 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa240-269, APC) - LS-C246883 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa240-269, Biotin) - LS-C246884 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa240-269, FITC) - LS-C246885 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa240-269, Azide-free, HRP) - LS-C249904 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa271-299) - LS-C167739 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of ELOVL5 Antibody in HeLa cell line lysates (35 ug/lane). ELOVL5 (arrow) was detected using the purified antibody.

Anti-HELO1 / ELOVL5 Antibody (aa271-299, Azide-free, HRP) - LS-C249906 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa247-277) - LS-C321100 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (aa270-299) - LS-C321101 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HELO1 / ELOVL5 Antibody (Internal) IHC-plus™ - LS-A8396 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ELOVL5 antibody LS-A8396 IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Search more