ELOVL5

Gene Symbol ELOVL5
Entrez Gene 60481
Alt Symbol HELO1, SCA38, dJ483K16.1
Species Human
Gene Type protein-coding
Description ELOVL fatty acid elongase 5
Other Description 3-keto acyl-CoA synthase ELOVL5|ELOVL FA elongase 5|ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)|elongation of very long chain fatty acids protein 5|fatty acid elongase 1|homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2|spinocerebellar ataxia 38|very-long-chain 3-oxoacyl-CoA synthase 5
Swissprots B4DZJ2 Q9NYP7 Q8NCG4 Q6NXE7 Q9UI22 F6SH78 Q7L2S5 Q59EL3 Q5TGH5
Accessions CAF86084 EAX04413 EAX04414 EAX04415 EAX04416 EAX04417 EAX04418 EAX04419 EAX04420 EAX04421 EAX04422 Q9NYP7 AB209798 BAD93035 AF052129 AF111849 AAF16688 AF231981 AAF70631 AF338241 AAM00193 AK074748 BAC11178 AK074889 BAC11270 AK125098 BAG54141 AK299674 BAG61584 AK302948 BAG64104 AL136939 CAB66873 BC009838 BC017270 AAH17270 BC067123 AAH67123 BC074503 DB143083 DB225467 DC345924 DQ980601 HQ447433 ADQ31919 NM_001242828 NP_001229757 NM_001242830 NP_001229759 NM_001242831 NP_001229760 NM_001301856 NP_001288785 NM_021814 NP_068586
Function Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:10970790, ECO:0000269|PubMed:20937905}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:25065913}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. {ECO:0000269|PubMed:25065913}.
Tissue Specificity Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum. {ECO:0000269|PubMed:10970790, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:25065913}.
Top Pathways Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

ELOVL5 CRISPR/Cas9 KO Plasmid (h) - sc-417429 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL5 HDR Plasmid (h) - sc-417429-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL5 Double Nickase Plasmid (h) - sc-417429-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL5 Double Nickase Plasmid (h2) - sc-417429-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL5 CRISPR Activation Plasmid (h) - sc-417429-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL5 CRISPR Activation Plasmid (h2) - sc-417429-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL5 Lentiviral Activation Particles (h) - sc-417429-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL5 Lentiviral Activation Particles (h2) - sc-417429-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL5 siRNA (h) - sc-62269 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ELOVL5 shRNA Plasmid (h) - sc-62269-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ELOVL5 shRNA (h) Lentiviral Particles - sc-62269-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU002751 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7824 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7824 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12744 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12744

ELOVL5 siRNA (Human) - CRJ1796 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ELOVL5 - MBS8207354 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ELOVL5 (NM_021814.4) - SHH285293 from Creative biogene

Category siRNA
Species Reactivities Human

Human ELOVL5 siRNA - orb272297 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ELOVL5 shRNA Plasmid (Human) - CHJ1796 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ELOVL5 miRNA 3'UTR clone - MiUTR3H-12114 from Creative biogene

Species Reactivities Human
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