ELOVL5

Gene Symbol	ELOVL5
Entrez Gene	60481
Alt Symbol	HELO1, SCA38, dJ483K16.1
Species	Human
Gene Type	protein-coding
Description	ELOVL fatty acid elongase 5
Other Description	3-keto acyl-CoA synthase ELOVL5|ELOVL FA elongase 5|ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)|elongation of very long chain fatty acids protein 5|fatty acid elongase 1|homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2|spinocerebellar ataxia 38|very-long-chain 3-oxoacyl-CoA synthase 5
Swissprots	B4DZJ2 Q9NYP7 Q8NCG4 Q6NXE7 Q9UI22 F6SH78 Q7L2S5 Q59EL3 Q5TGH5
Accessions	CAF86084 EAX04413 EAX04414 EAX04415 EAX04416 EAX04417 EAX04418 EAX04419 EAX04420 EAX04421 EAX04422 Q9NYP7 AB209798 BAD93035 AF052129 AF111849 AAF16688 AF231981 AAF70631 AF338241 AAM00193 AK074748 BAC11178 AK074889 BAC11270 AK125098 BAG54141 AK299674 BAG61584 AK302948 BAG64104 AL136939 CAB66873 BC009838 BC017270 AAH17270 BC067123 AAH67123 BC074503 DB143083 DB225467 DC345924 DQ980601 HQ447433 ADQ31919 NM_001242828 NP_001229757 NM_001242830 NP_001229759 NM_001242831 NP_001229760 NM_001301856 NP_001288785 NM_021814 NP_068586
Function	Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:10970790, ECO:0000269|PubMed:20937905}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:25065913}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. {ECO:0000269|PubMed:25065913}.
Tissue Specificity	Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum. {ECO:0000269|PubMed:10970790, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:25065913}.
Top Pathways	Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HELO1 / ELOVL5 Antibody Blocking Peptide - LS-E1971 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HELO1 / ELOVL5 Antibody Blocking Peptide - LS-E29403 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HELO1 / ELOVL5 Antibody Blocking Peptide - LS-E29404 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HELO1 / ELOVL5 Antibody Blocking Peptide - LS-E29405 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HELO1 / ELOVL5 Antibody Blocking Peptide - LS-E10424 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HELO1 / ELOVL5 Antibody Blocking Peptide - LS-E29789 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ELOVL5-Antibody-C-term-Blocking-peptide - BP12826b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ELOVL5-Antibody-C-term-Blocking-Peptide - BP9968a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ELOVL5 Blocking Peptide - 33R-2451 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ELOVL5 fusion protein - ag13443 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ELOVL5 Blocking Peptide - abx161842 from Abbexa Category Peptide Species Human, Monkey

ELOVL5 Recombinant Protein Antigen - NBP2-33500PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ELOVL5 Peptide, Human - M34GP04879H from Creative Peptides Category Peptide Source Synthetic. Species Human

ELOVL5 Blocking Peptide - CBP4631 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

ELOVL5 Blocking Peptide - orb392976 from Biorbyt Category Peptide Prices $238.00, $476.00 Sizes 1 mg, 5 mg Species Human, Mouse

ELOVL5 Recombinant Protein Antigen - NBP2-58784PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Elongation of very long chain fatty acids protein 5 (ELOVL5), Recombinant Protein - MBS7014217 from MyBioSource Category Protein Prices $1,110.00, $2,095.00, $3,305.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

ELOVL5 fusion protein - Ag24786 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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