| Gene Symbol |
MARCH5
|
| Entrez Gene |
54708
|
| Alt Symbol |
MARCH-V, MITOL, RNF153
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane-associated ring finger (C3HC4) 5
|
| Other Description |
E3 ubiquitin-protein ligase MARCH5|membrane-associated RING finger protein 5|membrane-associated RING-CH protein V|mitochondrial ubiquitin ligase|ring finger protein 153
|
| Swissprots |
Q9NX47
|
| Accessions |
EAW50094 EAW50095 EAW50096 Q9NX47 AB191202 BAF02285 AK000452 BAA91173 AK294799 BAG57919 AK309175 BC015480 AAH15480 BE393612 JF432871 ADZ16088 XM_011539886 XP_011538188 NM_017824 NP_060294
|
| Function |
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. {ECO:0000269|PubMed:16874301, ECO:0000269|PubMed:17606867, ECO:0000269|PubMed:19741096, ECO:0000269|PubMed:20103533}.
|
| Subcellular Location |
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301). {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:16874301}.
|
| Tissue Specificity |
Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle. {ECO:0000269|PubMed:16874301}.
|