BLOC1S2

Gene Symbol BLOC1S2
Entrez Gene 282991
Alt Symbol BLOS2, CEAP, CEAP11
Species Human
Gene Type protein-coding
Description biogenesis of lysosomal organelles complex-1, subunit 2
Other Description 11 kDa centrosome associated protein|BLOC-1 subunit 2|biogenesis of lysosome-related organelles complex 1 subunit 2|centrosomal 10 kDa protein|centrosome protein oncogene
Swissprots Q8WUI8 Q5W040 B4DQV2 Q6QNY1
Accessions EAW49835 EAW49836 EAW49837 Q6QNY1 AB593084 BAJ84024 AK054697 AK298969 BAG61064 AY278457 AAQ19606 AY531265 AAT00461 BC020494 AAH20494 BF666010 BG545838 BG679165 BI753469 BU608851 BU740315 BX112121 CB118026 CB218039 CN340962 DB296446 DB456773 HY107885 HY165508 NM_001001342 NP_001001342 NM_001282436 NP_001269365 NM_001282437 NP_001269366 NM_001282438 NP_001269367 NM_001282439 NP_001269368 NM_173809 NP_776170
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in cell proliferation. {ECO:0000269|PubMed:15102850, ECO:0000269|PubMed:15381421, ECO:0000269|PubMed:17182842}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15381421}. Note=Localizes to the centrosomes in a microtubule-dependent manner.
Tissue Specificity Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level). {ECO:0000269|PubMed:15381421}.

BLOS2 (I-12) - sc-161392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BLOS2 (I-12): sc-sc-161392. Western blot analysis of BLOS2 expression in HeLa (A), LADMAC (B), WI 38 (C) whole cell lysates and mouse spleen (D) tissue extract.

BLOS2 (E-14) - sc-161391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-BLOC1S2 antibody - ab174929 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-BLOC1S2 antibody (ab174929) at 1/1000 dilution + NIH 3T3 cell lysate at 15 µg

Anti-BLOC1S2 antibody - ab125506 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-BLOC1S2 antibody (ab125506) at 1 µg/ml + Mouse heart lysate at 10 µgSecondaryGoat anti-Rabbit IgG-HRP

Anti-BLOC1S2 Antibody (aa14-40, AP) - LS-C233160 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BLOC1S2 Antibody (aa14-40, APC) - LS-C233161 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BLOC1S2 Antibody (aa14-40, Biotin) - LS-C233162 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BLOC1S2 Antibody (aa14-40, FITC) - LS-C233163 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BLOC1S2 Antibody (aa14-40, PE) - LS-C233166 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BLOC1S2 Antibody (aa14-40, Azide-free, HRP) - LS-C249525 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BLOC1S2 Antibody (aa31-80) - LS-C146428 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BLOC1S2 antibody LS-C146428 Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.

Anti-BLOC1S2 Antibody (aa21-50) - LS-C319847 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BLOC1S2 Antibody (aa14-40) - LS-C156827 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
BLOC1S2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cervix carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

BLOC1S2 Antibody - NBP2-14357 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: BLOC1S2 Antibody [NBP2-14357] Staining of human rectum shows strong cytoplasmic positivity in glandular cells.

BLOC1S2 Antibody (8C10) - H00282991-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8C10
Western Blot: BLOC1S2 Antibody (8C10) [H00282991-M01] - Analysis of BLOC1S2 expression in transfected 293T cell line by BLOC1S2 monoclonal antibody (M01), clone 8C10.Lane 1: BLOC1S2 transfected lysate (Predicted MW: 16 KDa).Lane 2: Non-transfected lysate.

Anti-BLOC1S2 antibody produced in rabbit - HPA048088 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-BLOC1S2:<B>Cat. No. HPA048088</B>: Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells.

ANTI-BLOC1S2 (CENTER) antibody produced in rabbit - SAB1301092 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>BLOC1S2 (Center): <B>Cat. No. SAB1301092</B>: BLOC1S2 in Human breast carcinoma tissue with BLOC1S2 antibody (Center) at 5 μg/mL.

BLOC1S2 Antibody - middle region (OAAB02952) - OAAB02952 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

BLOC1S2-Antibody-Center - AP5538c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
BLOC1S2 Antibody (Center) (Cat. #AP5538c) western blot analysis in HepG2 cell line lysates (15ug/lane).This demonstrates the BLOC1S2 antibody detected the BLOC1S2 protein (arrow).
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