PRKCE

Gene Symbol	PRKCE
Entrez Gene	5581
Alt Symbol	PKCE, nPKC-epsilon
Species	Human
Gene Type	protein-coding
Description	protein kinase C, epsilon
Other Description	protein kinase C epsilon type
Swissprots	Q9UE81 Q02156 Q53SM5 B0LPH7 Q53SL4 Q32MQ3
Accessions	AAD08855 AAX93119 AAX93253 AAY14773 ABY87556 AGC09605 EAX00257 EAX00258 EAX00259 Q02156 AK128749 AK313842 BAG36574 AL832345 BC029576 BC051195 BC054052 BC109033 AAI09034 BC109034 AAI09035 CA424727 X65293 CAA46388 XM_005264428 XP_005264485 XM_005264429 XP_005264486 XM_005264431 XP_005264488 XM_006712050 XP_006712113 XM_011532970 XP_011531272 XM_011532971 XP_011531273 XM_011532972 XP_011531274 XM_011532973 XP_011531275 XM_011532974 XP_011531276 XM_011532975 XP_011531277 XM_011532976 XP_011531278 XM_011532977 XP_011531279 XM_011532978 XP_011531280 XM_011532979 XP_011531281 XM_011532980 XP_011531282 XM_011532981 XP_011531283 XM_011532982 XP_011531284 XM_011532983 XP_011531285 XR_939695 NM_005400 NP_005391
Function	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17603037}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17603037}. Cell membrane {ECO:0000269|PubMed:17603037}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA- treated cells (By similarity). {ECO:0000250}.
Top Pathways	Vascular smooth muscle contraction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Inflammatory mediator regulation of TRP channels, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® PKCε Kinase Assay Kit - 7815 from Cell Signaling Technology Category Assay Kit

Mouse PRKCE / PKC-Epsilon ELISA Kit (Sandwich ELISA) - LS-F4288 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.125 ng/ml Range 1.56-100 ng/ml

Human PRKCE / PKC-Epsilon ELISA Kit (Sandwich ELISA) - LS-F4287 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.57 ng/ml Range 1.56-100 ng/ml

Mouse/Human/Rat Phospho-PRKCE / PKC-Epsilon (Ser729) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1303 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 1.56-100 ng/ml

Mouse/Human/Rat PRKCE / PKC-Epsilon ELISA Kit (Cell-Based ELISA) - LS-F2250 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 1.56-100 ng/ml

Rat PRKCE / PKC-Epsilon ELISA Kit (Sandwich ELISA) - LS-F9167 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.063 ng/ml Range 1.56-100 ng/ml

Human PRKCE / PKC-Epsilon ELISA Kit (Sandwich ELISA) - LS-F11901 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 1.56 Range 1.56-100 ng/ml

Human PKCe ELISA Kit - abx152754 from Abbexa Category ELISA Kit Sensitivity 0.60 ng/ml Range 1.563 ng/ml - 100 ng/ml

Protein Kinase C Epsilon, PKCe, Human, ELISA Kit - E-EL-H1181 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

Protein Kinase C Epsilon (PKCe), Human, ELISA Kit - SEA439Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.58ng/mL Range 1.56-100ng/mL

Protein kinase C epsilon type, PRKCE, Human, ELISA Kit - E8827h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 1.56-100 ng/mL

Protein Kinase C Epsilon, PKCe, Mouse, ELISA Kit - E-EL-M0975 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Protein Kinase C Epsilon, PKCE, Rat, ELISA Kit - E-EL-R0810 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Protein Kinase C Epsilon (PKCe), Human, CLIA Kit - SCA439Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 0.51ng/mL Range 1.56-100ng/mL

Human PKCe ELISA Kit - HP0109 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PKCe ELISA Kit - AP0109 from NeoScientific Category ELISA Kit Prices $380.00, $620.00 Sizes 100 µl, 200 µl

PKC epsilon Colorimetric Cell-Based ELISA Kit - CB5564 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PKC epsilon (Phospho-Ser729) Colorimetric Cell-Based ELISA Kit - CBP1307 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PKCe, ELISA Kit - MBS2504627 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

PKCE, ELISA Kit - MBS2501047 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Rat PKCe is 0.094ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.156-10ng/mL

PKCepsilon, ELISA Kit - MBS2502703 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

PKCepsilon, ELISA Kit - MBS2507113 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKCepsilon, ELISA Kit - MBS2511477 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKCepsilon, ELISA Kit - MBS2508663 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKCepsilon, ELISA Kit - MBS2505695 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563--100ng/mL

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