PRKCE
| Gene Symbol | PRKCE |
|---|---|
| Entrez Gene | 5581 |
| Alt Symbol | PKCE, nPKC-epsilon |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase C, epsilon |
| Other Description | protein kinase C epsilon type |
| Swissprots | Q9UE81 Q02156 Q53SM5 B0LPH7 Q53SL4 Q32MQ3 |
| Accessions | AAD08855 AAX93119 AAX93253 AAY14773 ABY87556 AGC09605 EAX00257 EAX00258 EAX00259 Q02156 AK128749 AK313842 BAG36574 AL832345 BC029576 BC051195 BC054052 BC109033 AAI09034 BC109034 AAI09035 CA424727 X65293 CAA46388 XM_005264428 XP_005264485 XM_005264429 XP_005264486 XM_005264431 XP_005264488 XM_006712050 XP_006712113 XM_011532970 XP_011531272 XM_011532971 XP_011531273 XM_011532972 XP_011531274 XM_011532973 XP_011531275 XM_011532974 XP_011531276 XM_011532975 XP_011531277 XM_011532976 XP_011531278 XM_011532977 XP_011531279 XM_011532978 XP_011531280 XM_011532979 XP_011531281 XM_011532980 XP_011531282 XM_011532981 XP_011531283 XM_011532982 XP_011531284 XM_011532983 XP_011531285 XR_939695 NM_005400 NP_005391 |
| Function | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17603037}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17603037}. Cell membrane {ECO:0000269|PubMed:17603037}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA- treated cells (By similarity). {ECO:0000250}. |
| Top Pathways | Vascular smooth muscle contraction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Inflammatory mediator regulation of TRP channels, MicroRNAs in cancer |
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