| Gene Symbol | DEFB114 |
|---|---|
| Entrez Gene | 245928 |
| Alt Symbol | DEFB-14, DEFB14 |
| Species | Human |
| Gene Type | protein-coding |
| Description | defensin, beta 114 |
| Other Description | beta-defensin 114|beta-defensin 14|defensin, beta 14 |
| Swissprots | Q30KQ6 Q8NES9 |
| Accessions | Q30KQ6 AY122470 AAM93912 BC156851 AAI56852 DQ012018 AAY59754 NM_001037499 NP_001032588 |
| Function | Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS- induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. {ECO:0000269|PubMed:23482568}. |
| Subcellular Location | Secreted {ECO:0000250}. |
| Tissue Specificity | Expressed in epididymis, predominantly in the caput (at protein level). {ECO:0000269|PubMed:23482568}. |
DEFB114 overexpression lysate - LY421915 from Acris Antibodies
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