| Gene Symbol |
XYLT2
|
| Entrez Gene |
64132
|
| Alt Symbol |
PXYLT2, XT-II, XT2, xylT-II
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
xylosyltransferase II
|
| Other Description |
UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase|peptide O-xylosyltransferase 1|protein xylosyltransferase 2|xylosyltransferase 2
|
| Swissprots |
Q9H1B5 Q6UY41 Q86V00
|
| Accessions |
EAW94626 EAW94627 Q9H1B5 AJ277442 CAC16788 AK299999 BAG61818 AL833210 AY358090 AAQ88457 BC017084 BC036069 BC052262 AAH52262 BC156444 AAI56445 BM726479 BQ018370 XM_005257572 XP_005257629 XM_011525114 XP_011523416 NM_022167 NP_071450 NR_110010
|
| Function |
Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity). Its enzyme activity has not been demonstrated. {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Expressed at higher level in kidney and pancreas. {ECO:0000269|PubMed:11099377}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|