Sirt6

Gene Symbol	Sirt6
Entrez Gene	50721
Alt Symbol	2810449N18Rik, AI043036, Sir2l6
Species	Mouse
Gene Type	protein-coding
Description	sirtuin 6
Other Description	NAD-dependent deacetylase sirtuin-6|NAD-dependent protein deacetylase sirtuin-6|SIR2-like protein 6|regulatory protein SIR2 homolog 6
Swissprots	P59941
Accessions	EDL31388 EDL31389 P59941 AK013316 AK145929 BAE26760 AK164625 BC052763 AAH52763 BY606083 CJ302020 XM_006513861 XP_006513924 XM_006513863 XP_006513926 XM_011243507 XP_011241809 NM_001163430 NP_001156902 NM_181586 NP_853617
Function	NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (By similarity). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the p
Subcellular Location	Nucleus {ECO:0000269|PubMed:15795229, ECO:0000269|PubMed:16439206}. Note=Predominantly nuclear. Associated with chromatin.
Tissue Specificity	Highest levels are found in muscle, thymus, spleen, brain and heart (at protein level). {ECO:0000269|PubMed:15795229, ECO:0000269|PubMed:16439206}.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

NAD-dependent deacetylase sirtuin-6, Sirt6, Mouse, ELISA Kit - E2127m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Sirtuin 6 (SIRT6), Mouse, ELISA Kit - SEE916Mu from ARP American Research Products Category ELISA Kit Prices $740.00 Sizes 96 t Sensitivity 0.063ng/mL Range 0.156-10ng/mL

sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) , ELISA Kit - MBS9320123 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 6, ELISA Kit - MBS058554 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Sirtuin 6 (SIRT6) - SEE916Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.063ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse Sirtuin 6 (SIRT6) ELISA Kit - EKU07358 from Biomatik Category ELISA Kit Prices $756.00, $3,326.00, $6,048.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.059 ng/mL Range 0.156-10 ng/mL

Mouse Sirtuin 6 ELISA Kit - abx154679 from Abbexa Category ELISA Kit Sensitivity 0.063 ng/ml Range 0.156 ng/ml - 10 ng/ml

Sirtuin 6 (SIRT6), Mouse, ELISA Kit - DL-SIRT6-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.156-10 ng/mL

Mouse SIRT6 ELISA Kit - abx571605 from Abbexa Category ELISA Kit Sensitivity 0.063 ng/ml Range 0.156 ng/ml - 10 ng/ml

Mouse Sirt6 ELISA Kit - E061067 from Biobool Category ELISA Kit

SIRT6 ELISA Kit (Mouse) (OKCD02892) - OKCD02892 from Aviva Systems Biology Category ELISA Kit Prices $555.00 Sizes 10 ng Sensitivity 0.059 ng/mL Range 0.156-10 ng/mL

Mouse NAD-dependent deacetylase sirtuin-6 (SIRT6) ELISA Kit - AE19467MO from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.059 ng/mL Range 0.156-10 ng/mL

NAD-dependent deacetylase sirtuin-6, ELISA Kit - MBS2885961 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 6 (SIRT6), ELISA Kit - MBS453008 from MyBioSource Category ELISA Kit Prices $425.00, $560.00, $2,480.00, $4,820.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.063ng/mL Range 0.156-10ng/mL

SIRT6 ELISA Kit (Mouse) (OKEH07155) - OKEH07155 from Aviva Systems Biology Category ELISA Kit Sensitivity 0.156 ng/mL Range 0.156 - 10 ng/mL

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