| Gene Symbol |
Sirt6
|
| Entrez Gene |
50721
|
| Alt Symbol |
2810449N18Rik, AI043036, Sir2l6
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
sirtuin 6
|
| Other Description |
NAD-dependent deacetylase sirtuin-6|NAD-dependent protein deacetylase sirtuin-6|SIR2-like protein 6|regulatory protein SIR2 homolog 6
|
| Swissprots |
P59941
|
| Accessions |
EDL31388 EDL31389 P59941 AK013316 AK145929 BAE26760 AK164625 BC052763 AAH52763 BY606083 CJ302020 XM_006513861 XP_006513924 XM_006513863 XP_006513926 XM_011243507 XP_011241809 NM_001163430 NP_001156902 NM_181586 NP_853617
|
| Function |
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (By similarity). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the p
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15795229, ECO:0000269|PubMed:16439206}. Note=Predominantly nuclear. Associated with chromatin.
|
| Tissue Specificity |
Highest levels are found in muscle, thymus, spleen, brain and heart (at protein level). {ECO:0000269|PubMed:15795229, ECO:0000269|PubMed:16439206}.
|
| Top Pathways |
Central carbon metabolism in cancer
|