Sirt6

Gene Symbol	Sirt6
Entrez Gene	50721
Alt Symbol	2810449N18Rik, AI043036, Sir2l6
Species	Mouse
Gene Type	protein-coding
Description	sirtuin 6
Other Description	NAD-dependent deacetylase sirtuin-6|NAD-dependent protein deacetylase sirtuin-6|SIR2-like protein 6|regulatory protein SIR2 homolog 6
Swissprots	P59941
Accessions	EDL31388 EDL31389 P59941 AK013316 AK145929 BAE26760 AK164625 BC052763 AAH52763 BY606083 CJ302020 XM_006513861 XP_006513924 XM_006513863 XP_006513926 XM_011243507 XP_011241809 NM_001163430 NP_001156902 NM_181586 NP_853617
Function	NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (By similarity). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the p
Subcellular Location	Nucleus {ECO:0000269|PubMed:15795229, ECO:0000269|PubMed:16439206}. Note=Predominantly nuclear. Associated with chromatin.
Tissue Specificity	Highest levels are found in muscle, thymus, spleen, brain and heart (at protein level). {ECO:0000269|PubMed:15795229, ECO:0000269|PubMed:16439206}.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse Sirtuin 6 Protein - abx069109 from Abbexa Category Protein Source E.coli Species Mouse

Sirtuin 6 (SIRT6), Mouse - 20-9030 from ARP American Research Products Category Protein Prices $429.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant Sirtuin 6 (SIRT6) - RPE916Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Sirtuin 6 (SIRT6) - RPE916Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse NAD-dependent protein deacetylase sirtuin-6(Sirt6) - CSB-YP021344MO CSB-EP021344MO CSB-BP021344MO CSB-MP021344MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Sirtuin 6 (SIRT6) - RPU143829 from Biomatik Category Protein Prices $198.00, $396.00, $594.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Recombinant Sirtuin 6 (SIRT6) - RPU43829 from Biomatik Category Protein Prices $187.00, $324.00, $495.00, $619.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

SIRT6 Recombinant Protein (OPCD07012) - OPCD07012 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

NAD-dependent protein deacetylase sirtuin-6 (Sirt6), Recombinant Protein - MBS967929 from MyBioSource Category Protein Prices $1,680.00, $2,140.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Sirtuin 6 (SIRT6), Recombinant Protein - MBS2009930 from MyBioSource Category Protein Prices $165.00, $325.00, $505.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

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