NDRG1

Gene Symbol	NDRG1
Entrez Gene	10397
Alt Symbol	CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
Species	Human
Gene Type	protein-coding
Description	N-myc downstream regulated 1
Other Description	N-myc downstream-regulated gene 1 protein|differentiation-related gene 1 protein|nickel-specific induction protein Cap43|protein NDRG1|protein regulated by oxygen-1|reducing agents and tunicamycin-responsive protein
Swissprots	B7Z446 Q92597 Q6IBG2 Q9UK29 Q9NYR6 B3KR80 O15207
Accessions	EAW92164 EAW92165 EAW92166 Q92597 AF004162 AAC13419 AF039944 AF147402 AF230380 AAF71305 AK091147 BAG52292 AK091269 AK095649 BAC04597 AK096562 BAG53324 AK124709 BAG54074 AK126924 BAG54400 AK129867 AK130985 AK223542 BAD97262 AK296794 BAH12432 AK297342 BAH12556 AK298236 BAH12741 AK299636 BAH13083 AK307829 AK308117 AU141826 AY277597 AAQ18036 BC003175 AAH03175 BC006260 BX648361 CR456842 CAG33123 D87953 BAA13505 DC343351 DC353531 DQ892952 ABM83878 DQ896199 ABM87198 X92845 CAA63430 XM_011516791 XP_011515093 XM_011516792 XP_011515094 NM_001135242 NP_001128714 NM_001258432 NP_001245361 NM_001258433 NP_001245362 NM_006096 NP_006087
Function	Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}.
Subcellular Location	Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and wi
Tissue Specificity	Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression. {ECO:0000269|PubMed:12432451, ECO:0000269|PubMed:8939898, ECO:0000269|PubMed:9251681, ECO:0000269|PubMed:9605764}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NDRG1 ELISA Kit (Sandwich ELISA) - LS-F12130 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 Range 0.625-40 ng/ml

Protein NDRG1 (NDRG1), Human, ELISA Kit - CSB-EL015610HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7 pg/ml Range 28 pg/ml-1800 pg/ml

Protein NDRG1, NDRG1, Human, ELISA Kit - E14498h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.625-40 ng/mL

N-myc downstream regulated 1, ELISA Kit - MBS926360 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human NDRG1 is typically less than 7 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 28 pg/ml -1800 pg/ml.

Human Protein NDRG1(NDRG1) ELISA kit - CSB-EL015610HU from Cusabio Category ELISA Kit Sensitivity 7pg/ml Range 28 pg/ml-1800 pg/ml

Mouse NDRG1 ELISA Kit (Custom ELISA) - LS-F17319 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.625-40 ng/ml

Bovine NDRG1 ELISA Kit (Custom ELISA) - LS-F17321 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.625-40 ng/ml

Rat NDRG1 ELISA Kit (Custom ELISA) - LS-F17320 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.625-40 ng/ml

Human Protein NDRG1 ELISA Kit - abx250909 from Abbexa Category ELISA Kit Range 0.625 ng/ml - 40 ng/ml

Human Protein NDRG1 (NDRG1) ELISA Kit - EKC35224 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 7 pg/ml Range 28 pg/ml-1800 pg/ml

Human Protein NDRG1 ELISA Kit - EKE54996 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.21 ng/ml Range 0.625-40 ng/mL

NDRG1 - EKH3234 from Nordic BioSite Sensitivity 0.375ng/ml Range 0.625-40ng/ml

NDRG1 ELISA Kit (Human) : 96 Wells (OKEH02359) - OKEH02359 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.21 ng/mL Range 0.625 - 40 ng/mL

Human NDRG1 ELISA Kit - E025681 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human NDRG1 is typically less than 7 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O

Human Protein NDRG1 ELISA Kit - EK3420 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 0.21ng/ml Range 0.625-40 ng/mL

anti-NDRG1 antibody - ARG63597 from Arigo Biolaboratories Category ELISA Kit

anti-NDRG1 antibody [11G4] - ARG57159 from Arigo Biolaboratories Category ELISA Kit

NDRG1, ELISA Kit - MBS9427254 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 0.21ng/mL Range 0.625-40 ng/mL

NDRG1, ELISA Kit - MBS289604 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.625-40 ng/mL

Protein NDRG1, ELISA Kit - MBS760516 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/ml Range 0.625-40ng/ml

Human NDRG1 ELISA Kit (Sandwich ELISA) - LS-F33586 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.375 Range 0.625-40 ng/ml

Search more