| Gene Symbol |
NDRG1
|
| Entrez Gene |
10397
|
| Alt Symbol |
CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-myc downstream regulated 1
|
| Other Description |
N-myc downstream-regulated gene 1 protein|differentiation-related gene 1 protein|nickel-specific induction protein Cap43|protein NDRG1|protein regulated by oxygen-1|reducing agents and tunicamycin-responsive protein
|
| Swissprots |
B7Z446 Q92597 Q6IBG2 Q9UK29 Q9NYR6 B3KR80 O15207
|
| Accessions |
EAW92164 EAW92165 EAW92166 Q92597 AF004162 AAC13419 AF039944 AF147402 AF230380 AAF71305 AK091147 BAG52292 AK091269 AK095649 BAC04597 AK096562 BAG53324 AK124709 BAG54074 AK126924 BAG54400 AK129867 AK130985 AK223542 BAD97262 AK296794 BAH12432 AK297342 BAH12556 AK298236 BAH12741 AK299636 BAH13083 AK307829 AK308117 AU141826 AY277597 AAQ18036 BC003175 AAH03175 BC006260 BX648361 CR456842 CAG33123 D87953 BAA13505 DC343351 DC353531 DQ892952 ABM83878 DQ896199 ABM87198 X92845 CAA63430 XM_011516791 XP_011515093 XM_011516792 XP_011515094 NM_001135242 NP_001128714 NM_001258432 NP_001245361 NM_001258433 NP_001245362 NM_006096 NP_006087
|
| Function |
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}.
|
| Subcellular Location |
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and wi
|
| Tissue Specificity |
Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression. {ECO:0000269|PubMed:12432451, ECO:0000269|PubMed:8939898, ECO:0000269|PubMed:9251681, ECO:0000269|PubMed:9605764}.
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