NDRG1

Gene Symbol	NDRG1
Entrez Gene	10397
Alt Symbol	CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
Species	Human
Gene Type	protein-coding
Description	N-myc downstream regulated 1
Other Description	N-myc downstream-regulated gene 1 protein|differentiation-related gene 1 protein|nickel-specific induction protein Cap43|protein NDRG1|protein regulated by oxygen-1|reducing agents and tunicamycin-responsive protein
Swissprots	B7Z446 Q92597 Q6IBG2 Q9UK29 Q9NYR6 B3KR80 O15207
Accessions	EAW92164 EAW92165 EAW92166 Q92597 AF004162 AAC13419 AF039944 AF147402 AF230380 AAF71305 AK091147 BAG52292 AK091269 AK095649 BAC04597 AK096562 BAG53324 AK124709 BAG54074 AK126924 BAG54400 AK129867 AK130985 AK223542 BAD97262 AK296794 BAH12432 AK297342 BAH12556 AK298236 BAH12741 AK299636 BAH13083 AK307829 AK308117 AU141826 AY277597 AAQ18036 BC003175 AAH03175 BC006260 BX648361 CR456842 CAG33123 D87953 BAA13505 DC343351 DC353531 DQ892952 ABM83878 DQ896199 ABM87198 X92845 CAA63430 XM_011516791 XP_011515093 XM_011516792 XP_011515094 NM_001135242 NP_001128714 NM_001258432 NP_001245361 NM_001258433 NP_001245362 NM_006096 NP_006087
Function	Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}.
Subcellular Location	Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and wi
Tissue Specificity	Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression. {ECO:0000269|PubMed:12432451, ECO:0000269|PubMed:8939898, ECO:0000269|PubMed:9251681, ECO:0000269|PubMed:9605764}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human NDRG1 full length protein - ab167974 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source E. coli Species Human

Active human NDRG1 full length protein - ab87685 from Abcam Category Protein Prices $192.00, $588.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human NDRG1 peptide - ab45488 from Abcam Category Peptide Species Human

NDRG1 Antibody Blocking Peptide - LS-E25453 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NDRG1 Antibody Blocking Peptide - LS-E8559 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NDRG1 Antibody Blocking Peptide - LS-E17362 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NDRG1 Recombinant Protein - H00010397-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NDRG1 Protein - NBP1-30231 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Species Human

NDRG1 Recombinant Protein - P3493 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

NDRG1-Antibody-N-term-Blocking-Peptide - BP6935a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NDRG1 blocking peptide - GTX41727-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

NDRG1 Protein (OPPA02108) - OPPA02108 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human N-Myc Downstream Regulated 1 protein - orb81232 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Source E.coli

Human NDRG1 protein - orb49614 from Biorbyt Category Protein Prices $366.00, $706.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human NDRG1 protein (His Tag) - orb139386 from Biorbyt Category Protein Prices $323.00, $434.00 Sizes 50 μg, 100 μg Source E. coli Species Human

NDRG1 Blocking Peptide - 33R-3588 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NDRG1 Blocking Peptide - 33R-6485 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NDRG1 Peptide - AC21-0282-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NDRG1 (1-394, His-tag) - AR09269PU-L from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

NDRG1 (1-394, His-tag) - AR09269PU-N from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

NDRG1 - H00010397-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NDRG1 - H00010397-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NDRG1 - P3493 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Human

N-Myc Downstream Regulated 1, Human Recombinant - 228-13180-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human N-Myc Downstream Regulated 1 - 228-13180-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Search more