IFITM1

Gene Symbol IFITM1
Entrez Gene 8519
Alt Symbol 9-27, CD225, DSPA2a, IFI17, LEU13
Species Human
Gene Type protein-coding
Description interferon induced transmembrane protein 1
Other Description dispanin subfamily A member 2a|interferon-induced protein 17|interferon-induced transmembrane protein 1|interferon-inducible protein 9-27|leu-13 antigen
Swissprots Q15322 Q53XZ0 P13164
Accessions AAB25699 EAW61218 EAW61219 P13164 AK290480 BAF83169 BC000897 AAH00897 BT007173 AAP35837 DQ891094 ABM82020 DQ894276 ABM85202 J04164 AAA35494 X84958 CAA59337 NM_003641 NP_003632
Function IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:2083
Subcellular Location Cell membrane {ECO:0000269|PubMed:19499152, ECO:0000269|PubMed:25105503}; Single-pass membrane protein {ECO:0000269|PubMed:19499152}.
Tissue Specificity Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines. {ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:22634173}.
Top Pathways B cell receptor signaling pathway

IFITM1 Antibody - 13126 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from K-562 cells, CD4 + T cells, and CD8 + T cells using IFITM1 Antibody.

IFITM1 (P-17) - sc-34171 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IFITM1 (P-17): sc-34171. Western blot analysis of IFITM1 expression in non-transfected 293: sc-110760 (A), human IFITM1 transfected 293: sc-110559 (B) and K-562 (C) whole cell lysates.

IFITM1/2/3 (F-12) - sc-374026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IFITM1/2/3 (F-12): sc-374026. Western blot analysis of IFITM1 expression in non-transfected: sc-110760 (A) and human IFITM1 transfected: sc-110559 (B) 293 whole cell lysates.

IFITM1/2/3 (FL-125) - sc-66827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IFITM1/2/3 (FL-125): sc-66827. Western blot analysis of IFITM1/2/3 expression in K-562 whole cell lysate.

IFITM1/2/3 (S-15) - sc-131566 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IFITM1/2/3 (V-15) - sc-131567 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IFITM1 antibody - ab106265 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Staining of IFITM1 in a formalin fixed, paraffin embedded section of Human intestine cancer using ab106265 at a concentration of 1 µg/ml.

Anti-IFITM1 antibody - ab117533 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab117533, at 5 µg/ml, staining IFITM1 in Formalin-fixed, Paraffin-embedded Human Uterus, myometrium tissue by Immunohistochemistry.

Anti-IFITM1 antibody - ab117519 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab117519, at 10 µg/ml, staining IFITM1 in in Formalin-fixed, Paraffin-embedded Human thymus tissue by Immunohistochemistry.

Anti-IFITM1 antibody - ab105465 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IFITM1 antibody (ab105465) at 1 µg/mlLane 1 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell LysateLane 2 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell Lysate with Immunising peptide at 1 µg/mlLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IFITM1 antibody - ab70477 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (aa2-17) - LS-C122003 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (N-Terminus, Sepharose) - LS-C171879 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (HRP) - LS-C211575 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (N-Terminus, Magnetic beads) - LS-C171878 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody - LS-C211576 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (FITC) - LS-C211577 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (aa37-66, APC) - LS-C259027 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (aa37-66, AP) - LS-C259916 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody - LS-C308391 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CD225 / IFITM1 Antibody - LS-C310707 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (Biotin) - LS-C211578 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (aa37-66, PE) - LS-C259028 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (aa37-66) - LS-C322154 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CD225 / IFITM1 Antibody (N-Terminus) - LS-C171877 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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