| Gene Symbol | IFITM1 |
|---|---|
| Entrez Gene | 8519 |
| Alt Symbol | 9-27, CD225, DSPA2a, IFI17, LEU13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon induced transmembrane protein 1 |
| Other Description | dispanin subfamily A member 2a|interferon-induced protein 17|interferon-induced transmembrane protein 1|interferon-inducible protein 9-27|leu-13 antigen |
| Swissprots | Q15322 Q53XZ0 P13164 |
| Accessions | AAB25699 EAW61218 EAW61219 P13164 AK290480 BAF83169 BC000897 AAH00897 BT007173 AAP35837 DQ891094 ABM82020 DQ894276 ABM85202 J04164 AAA35494 X84958 CAA59337 NM_003641 NP_003632 |
| Function | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:2083 |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:19499152, ECO:0000269|PubMed:25105503}; Single-pass membrane protein {ECO:0000269|PubMed:19499152}. |
| Tissue Specificity | Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines. {ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:22634173}. |
| Top Pathways | B cell receptor signaling pathway |
IFITM1 CRISPR/Cas9 KO Plasmid (h) - sc-416878 from Santa Cruz Biotechnology
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IFITM1 HDR Plasmid (h) - sc-416878-HDR from Santa Cruz Biotechnology
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IFITM1 Double Nickase Plasmid (h) - sc-416878-NIC from Santa Cruz Biotechnology
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IFITM1 Double Nickase Plasmid (h2) - sc-416878-NIC-2 from Santa Cruz Biotechnology
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IFITM1 CRISPR Activation Plasmid (h) - sc-416878-ACT from Santa Cruz Biotechnology
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IFITM1 CRISPR Activation Plasmid (h2) - sc-416878-ACT-2 from Santa Cruz Biotechnology
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IFITM1 Lentiviral Activation Particles (h) - sc-416878-LAC from Santa Cruz Biotechnology
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IFITM1 Lentiviral Activation Particles (h2) - sc-416878-LAC-2 from Santa Cruz Biotechnology
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IFITM1 siRNA (h) - sc-44549 from Santa Cruz Biotechnology
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IFITM1 shRNA Plasmid (h) - sc-44549-SH from Santa Cruz Biotechnology
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IFITM1 shRNA (h) Lentiviral Particles - sc-44549-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU107771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10470 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10470 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00977 from Sigma-Aldrich
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IFITM1 siRNA (Human) - CRH5592 from Cohesion Biosciences
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IFITM1 - MBS8202861 from MyBioSource
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shRNA set against Human IFITM1 (NM_003641.3) - SHH316949 from Creative biogene
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shRNA set against Human IFITM1(NM_003641.3) - SHL166194 from Creative biogene
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Human IFITM1 siRNA - orb266094 from Biorbyt
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IFITM1 shRNA Plasmid (Human) - CHH5592 from Cohesion Biosciences
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IFITM1 miRNA 3'UTR clone - MiUTR1H-04806 from Creative biogene
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