| Gene Symbol | IFITM1 |
|---|---|
| Entrez Gene | 8519 |
| Alt Symbol | 9-27, CD225, DSPA2a, IFI17, LEU13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon induced transmembrane protein 1 |
| Other Description | dispanin subfamily A member 2a|interferon-induced protein 17|interferon-induced transmembrane protein 1|interferon-inducible protein 9-27|leu-13 antigen |
| Swissprots | Q15322 Q53XZ0 P13164 |
| Accessions | AAB25699 EAW61218 EAW61219 P13164 AK290480 BAF83169 BC000897 AAH00897 BT007173 AAP35837 DQ891094 ABM82020 DQ894276 ABM85202 J04164 AAA35494 X84958 CAA59337 NM_003641 NP_003632 |
| Function | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:2083 |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:19499152, ECO:0000269|PubMed:25105503}; Single-pass membrane protein {ECO:0000269|PubMed:19499152}. |
| Tissue Specificity | Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines. {ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:22634173}. |
| Top Pathways | B cell receptor signaling pathway |