RAB13

Gene Symbol	RAB13
Entrez Gene	5872
Alt Symbol	GIG4
Species	Human
Gene Type	protein-coding
Description	RAB13, member RAS oncogene family
Other Description	RAS-associated protein RAB13|cell growth-inhibiting gene 4 protein|growth-inhibiting gene 4 protein|ras-related protein Rab-13
Swissprots	Q96GU4 P51153 Q6GPG6 Q5U0A6 A8K6B5 D3DV67
Accessions	EAW53248 EAW53249 EAW53250 P51153 AF498948 AAM21096 AK128675 AK291580 BAF84269 AM392651 CAL37529 AM393152 CAL38030 AM393265 CAL38143 AM393465 CAL38342 AM393739 CAL38614 AM393810 CAL38685 AY423722 AAS00485 BC000799 AAH00799 BC009227 AAH09227 BC073168 AAH73168 BC094846 AAH94846 BJ997167 BT019700 AAV38506 BT019701 AAV38507 BU188046 CN396084 X75593 CAA53266 NM_001272038 NP_001258967 NM_002870 NP_002861 NR_073553
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulatio
Subcellular Location	Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Relocalizes to the leading edge of lamellipodia in migrating endothelial cells.
Tissue Specificity	Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells.
Top Pathways	Tight junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAB13 full length protein - ab109958 from Abcam Category Protein Source E. coli Species Human

RAB13 Antibody Blocking Peptide - LS-E8371 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB13 Antibody Blocking Peptide - LS-E15783 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Rab13 Protein - H00005872-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Rab13 Protein - NBP1-72372 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

RAB13-Antibody-Center-Blocking-Peptide - BP6667c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human RAB13 protein - orb169130 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

RAB13 protein (His tag) - 80R-1883 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

RAB13 (1-200, His-tag) - AR39066PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

RAB13 (1-200, His-tag) - AR39066PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

RAB13 - H00005872-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

RAB13, Member RAS Oncogene Family, Human Recombinant - 228-13321-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human RAB13, Member RAS Oncogene Family - 228-13321-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human RAB13, Member RAS Oncogene Family - 228-13321-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

RAB13, 1-200aa, Human, His tag, E.coli - 11-RAB13 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

RAB13 fusion protein - Ag2292 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RAB13 Human - PRPS-889 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human RAB13, Member RAS Oncogene Family Protein - BP002328-PRO-882 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

RAB13, 1-200aa, Recombinant Protein - GWB-P0912B from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

Recombinant Human RAB13, His-tagged - RAB13-3592H from Creative Biomart Category Protein

Recombinant Human RAB13, His-tagged - RAB13-31040TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human RAB13, GST-tagged - RAB13-2100H from Creative Biomart Category Protein Source E.coli Species Human

RAB13 1-200aa - CMB-959 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 50.00 µg, 250.00 µg Source E.coli Species Human

Recombinant Human Ras-related protein Rab-13(RAB13) - CSB-YP019161HU CSB-EP019161HU CSB-BP019161HU CSB-MP019161HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RAB13, 1-200aa, Human, His tag, E.coli - ATGP1126 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

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