RAB13

Gene Symbol RAB13
Entrez Gene 5872
Alt Symbol GIG4
Species Human
Gene Type protein-coding
Description RAB13, member RAS oncogene family
Other Description RAS-associated protein RAB13|cell growth-inhibiting gene 4 protein|growth-inhibiting gene 4 protein|ras-related protein Rab-13
Swissprots Q96GU4 P51153 Q6GPG6 Q5U0A6 A8K6B5 D3DV67
Accessions EAW53248 EAW53249 EAW53250 P51153 AF498948 AAM21096 AK128675 AK291580 BAF84269 AM392651 CAL37529 AM393152 CAL38030 AM393265 CAL38143 AM393465 CAL38342 AM393739 CAL38614 AM393810 CAL38685 AY423722 AAS00485 BC000799 AAH00799 BC009227 AAH09227 BC073168 AAH73168 BC094846 AAH94846 BJ997167 BT019700 AAV38506 BT019701 AAV38507 BU188046 CN396084 X75593 CAA53266 NM_001272038 NP_001258967 NM_002870 NP_002861 NR_073553
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulatio
Subcellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Relocalizes to the leading edge of lamellipodia in migrating endothelial cells.
Tissue Specificity Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells.
Top Pathways Tight junction

Rab 13 (K-15) - sc-30375 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Rab 13 (K-15): sc-30375. Western blot analysis of Rab 13 expression in non-transfected: sc-110760 (A) and human Rab 13 transfected: sc-110521 (B) 293 whole cell lysates.

Rab 13 (W-16) - sc-30374 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Rab 13 (W-16): sc-30374. Western blot analysis of Rab 13 expression in non-transfected: sc-117752 (A) and human Rab 13 transfected: sc-129574 (B) 293T whole cell lysates.

Anti-RAB13 antibody - ab55889 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RAB13 antibody [EPR14109(B)] - ab180936 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14109(B)
All lanes : Anti-RAB13 antibody [EPR14109(B)] (ab180936) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : A431 cell lysateLysates/proteins at 10 µg per lane.SecondaryLane 1 : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilutionLane 2 : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 10 µg

Anti-RAB13 Antibody (N-Terminus) - LS-C46956 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RAB13 Antibody (aa91-140) - LS-C146089 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RAB13 antibody LS-C146089 Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.

Anti-RAB13 Antibody (clone 8H8) - LS-C198048 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8H8
RAB13 monoclonal antibody (M01), clone 8H8. Western Blot analysis of RAB13 expression in A-431.

Anti-RAB13 Antibody (aa109-137) - LS-C98402 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with RAB13 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Rab13 Antibody (863028) - MAB8305 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 863028
Western blot shows lysates of human lung tissue and human aorta tissue. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Rab13 Monoclonal Antibody (Catalog # MAB8305) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for Rab13 at approximately 23 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Rab13 Antibody - NBP1-85799 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Rab13 Antibody [NBP1-85799] - Analysis in human cell line MCF-7.

Rab13 Antibody - NB100-75545 from Novus Biologicals

Host Chicken
Clonality Polyclonal

Rab13 Antibody - NBP1-32656 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: RAB13 Antibody [NBP1-32656] - (30 ug of whole cell lysate) A: 293T B: A431 C: H1299 D: Hela S3 E: Hep G2 F: Molt-4 G: Raji 12 % SDS PAGE diluted at 1:1000

Rab13 Antibody (8H8) - H00005872-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8H8
Western Blot: Rab13 Antibody (8H8) [H00005872-M01] - RAB13 monoclonal antibody (M01), clone 8H8. Analysis of RAB13 expression in A-431.

Rab13 Antibody - H00005872-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Rab13 Antibody [H00005872-D01P] - Analysis of RAB13 expression in transfected 293T cell line by RAB13 polyclonal antibody.Lane 1: RAB13 transfected lysate(22.80 KDa).Lane 2: Non-transfected lysate.

Anti-Rab13 (C-terminal) antibody produced in rabbit - SAB4200058 from Sigma-Aldrich

Prices $61.10, $360.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>A431 cells were fixed and permeabilized with 4% paraformaldehyde followed by 0.5% Triton<SUP>™</SUP> X-100. Fixed cells were stained with 5 μg/mL Rabbit Anti-Rab13 (C-terminal) (<B>Cat. No. SAB4200058</B>). The antibody was developed using Goat Anti-Rabbit IgG, Atto 488 conjugate (<B>Cat. No. 18772</B>).Cells were counterstained with DAPI (blue) to stain nuclei (×100 magnification).

Anti-RAB13 antibody produced in rabbit - SAB1411177 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RAB13: <B>Cat. No. SAB1411177</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~22.8 kDa using RAB13 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-RAB13 antibody produced in rabbit - HPA003996 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RAB13: <B>Cat. No. HPA003996</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human fallopian tube tissue showing cytoplasmic staining of glandular cells.

Monoclonal Anti-RAB13 antibody produced in mouse - SAB1409591 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8H8
<B>Immunoblotting</B><BR/>Monoclonal Anti-RAB13: <B>Cat. No. SAB1409591</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~22.8 kDa using A-431 lysate.

RAB13-Antibody-Center - AP6667c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of RAB13 antibody (Center) (Cat. #AP6667c) in mouse bladder tissue lysates (35ug/lane). RAB13 (arrow) was detected using the purified Pab.

RAB13 Antibody - middle region (OAAB03711) - OAAB03711 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Human Rab13 Antibody - MAB8305 from R&D Systems

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clone 863028
Detection of Human Rab13 by Western Blot. Western blot shows lysates of human lung tissue and human aorta tissue. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Rab13 Monoclonal Antibody (Catalog # MAB8305) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018 ). A specific band was detected for Rab13 at approximately 23 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1 .

Human Rab13 MAb (Clone 863028), Mouse IgG2A - MAB8305-SP from R&D Systems

Host Mouse
Clonality Monoclonal
Clone 863028
Detection of Human Rab13 by Western Blot. Western blot shows lysates of human lung tissue and human aorta tissue. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Rab13 Monoclonal Antibody (Catalog # MAB8305) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for Rab13 at approximately 23 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

RAB13 (Center) antibody - AP17693PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of RAB13 antibody (Center) (AP17693PU-N) in mouse bladder tissue lysates (35ug/lane). RAB13 (arrow) was detected using the purified Pab.

RAB13 antibody - AP32612PU-N from Acris Antibodies

Prices $420.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot Analysis: PC12 lysate was resolved by electrophoresis, transferred to PVDF and probed with anti-RAB13 (1:1,000). Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates Rab13.

RAB13 antibody - H00005872-D01P from Acris Antibodies

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot analysis of RAB13 expression in transfected 293T cell line (H00005872-T02) by RAB13 MaxPab polyclonal antibody. Lane 1: RAB13 transfected lysate(22.80 KDa). Lane 2: Non-transfected lysate.
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