| Gene Symbol | RAB13 |
|---|---|
| Entrez Gene | 5872 |
| Alt Symbol | GIG4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAB13, member RAS oncogene family |
| Other Description | RAS-associated protein RAB13|cell growth-inhibiting gene 4 protein|growth-inhibiting gene 4 protein|ras-related protein Rab-13 |
| Swissprots | Q96GU4 P51153 Q6GPG6 Q5U0A6 A8K6B5 D3DV67 |
| Accessions | EAW53248 EAW53249 EAW53250 P51153 AF498948 AAM21096 AK128675 AK291580 BAF84269 AM392651 CAL37529 AM393152 CAL38030 AM393265 CAL38143 AM393465 CAL38342 AM393739 CAL38614 AM393810 CAL38685 AY423722 AAS00485 BC000799 AAH00799 BC009227 AAH09227 BC073168 AAH73168 BC094846 AAH94846 BJ997167 BT019700 AAV38506 BT019701 AAV38507 BU188046 CN396084 X75593 CAA53266 NM_001272038 NP_001258967 NM_002870 NP_002861 NR_073553 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulatio |
| Subcellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Relocalizes to the leading edge of lamellipodia in migrating endothelial cells. |
| Tissue Specificity | Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells. |
| Top Pathways | Tight junction |
Rab 13 CRISPR/Cas9 KO Plasmid (h) - sc-405802 from Santa Cruz Biotechnology
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Rab 13 HDR Plasmid (h) - sc-405802-HDR from Santa Cruz Biotechnology
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Rab 13 Double Nickase Plasmid (h) - sc-405802-NIC from Santa Cruz Biotechnology
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Rab 13 Double Nickase Plasmid (h2) - sc-405802-NIC-2 from Santa Cruz Biotechnology
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Rab 13 CRISPR Activation Plasmid (h) - sc-405802-ACT from Santa Cruz Biotechnology
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Rab 13 CRISPR Activation Plasmid (h2) - sc-405802-ACT-2 from Santa Cruz Biotechnology
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Rab 13 Lentiviral Activation Particles (h) - sc-405802-LAC from Santa Cruz Biotechnology
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Rab 13 Lentiviral Activation Particles (h2) - sc-405802-LAC-2 from Santa Cruz Biotechnology
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Rab 13 siRNA (h) - sc-44060 from Santa Cruz Biotechnology
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Rab 13 shRNA Plasmid (h) - sc-44060-SH from Santa Cruz Biotechnology
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Rab 13 shRNA (h) Lentiviral Particles - sc-44060-V from Santa Cruz Biotechnology
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Rab13 RNAi - H00005872-R01 from Novus Biologicals
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MISSION® esiRNA - EHU107931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17810 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17810 from Sigma-Aldrich
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RAB13 siRNA (Human) - CRH3962 from Cohesion Biosciences
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RAB13 - MBS8223288 from MyBioSource
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shRNA set against Human RAB13(NM_002870.2) - SHR157812 from Creative biogene
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Human RAB13 siRNA - orb264464 from Biorbyt
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RAB13 shRNA Plasmid (Human) - CHH3962 from Cohesion Biosciences
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RAB13 miRNA 3'UTR clone - MiUTR1H-08543 from Creative biogene
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