| Gene Symbol |
SSTR4
|
| Entrez Gene |
6754
|
| Alt Symbol |
SS-4-R, SS4-R, SS4R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
somatostatin receptor 4
|
| Other Description |
G-protein coupled receptor|somatostatin receptor type 4
|
| Swissprots |
Q17RM1 Q17RM3 P31391 Q9UIY1
|
| Accessions |
AAA36623 AAA60565 AAM22890 AAS55648 BAA04106 CBE74691 CDM63486 EAX10168 EAX10169 EAX10170 P31391 BC069063 AAH69063 BC117270 AAI17271 BC117272 AAI17273 NM_001052 NP_001043
|
| Function |
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|