Gene Symbol | SSTR4 |
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Entrez Gene | 6754 |
Alt Symbol | SS-4-R, SS4-R, SS4R |
Species | Human |
Gene Type | protein-coding |
Description | somatostatin receptor 4 |
Other Description | G-protein coupled receptor|somatostatin receptor type 4 |
Swissprots | Q17RM1 Q17RM3 P31391 Q9UIY1 |
Accessions | AAA36623 AAA60565 AAM22890 AAS55648 BAA04106 CBE74691 CDM63486 EAX10168 EAX10169 EAX10170 P31391 BC069063 AAH69063 BC117270 AAI17271 BC117272 AAI17273 NM_001052 NP_001043 |
Function | Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals. |
Top Pathways | Neuroactive ligand-receptor interaction |
SSTR4 CRISPR/Cas9 KO Plasmid (h) - sc-403781 from Santa Cruz Biotechnology
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SSTR4 HDR Plasmid (h) - sc-403781-HDR from Santa Cruz Biotechnology
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SSTR4 Double Nickase Plasmid (h) - sc-403781-NIC from Santa Cruz Biotechnology
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SSTR4 Double Nickase Plasmid (h2) - sc-403781-NIC-2 from Santa Cruz Biotechnology
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SSTR4 CRISPR Activation Plasmid (h) - sc-403781-ACT from Santa Cruz Biotechnology
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SSTR4 CRISPR Activation Plasmid (h2) - sc-403781-ACT-2 from Santa Cruz Biotechnology
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SSTR4 Lentiviral Activation Particles (h) - sc-403781-LAC from Santa Cruz Biotechnology
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SSTR4 Lentiviral Activation Particles (h2) - sc-403781-LAC-2 from Santa Cruz Biotechnology
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SSTR4 siRNA (h) - sc-42275 from Santa Cruz Biotechnology
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SSTR4 shRNA Plasmid (h) - sc-42275-SH from Santa Cruz Biotechnology
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SSTR4 shRNA (h) Lentiviral Particles - sc-42275-V from Santa Cruz Biotechnology
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Somatostatin R4/SSTR4 RNAi - H00006754-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN20637 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20637 from Sigma-Aldrich
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SSTR4 siRNA (Human) - CRH4617 from Cohesion Biosciences
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SSTR4 - MBS8206293 from MyBioSource
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shRNA set against Human SSTR4 (NM_001052.2) - SHH418604 from Creative biogene
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shRNA set against Human SSTR4(NM_001052.2) - SHL037002 from Creative biogene
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Human SSTR4 siRNA - orb265119 from Biorbyt
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SSTR4 shRNA Plasmid (Human) - CHH4617 from Cohesion Biosciences
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SSTR4 miRNA 3'UTR clone - MiUTR1H-09933 from Creative biogene
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