IFNLR1

Gene Symbol	IFNLR1
Entrez Gene	163702
Alt Symbol	CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2
Species	Human
Gene Type	protein-coding
Description	interferon, lambda receptor 1
Other Description	CRF2-12|IFN-lambda receptor 1|IFN-lambda-R1|IL-28 receptor subunit alpha|IL-28R-alpha|IL-28RA|class II cytokine receptor CRF2/12|cytokine receptor class-II member 12|cytokine receptor family 2 member 12|interferon lambda receptor 1|interferon lambda, receptor 1|interleukin 28 alpha receptor|interleukin 28 receptor A|interleukin 28 receptor, alpha (interferon, lambda receptor)|interleukin or cytokine receptor 2|interleukin-28 receptor subunit alpha|likely interleukin or cytokine receptor 2
Swissprots	Q5VTX7 Q5VTX5 Q6ZML8 Q8IZI7 Q5VTX8 Q8IV66 Q8IU57 Q8IZI8
Accessions	CAJ41832 CAV33829 EAW95113 EAW95114 EAW95115 EAW95116 EAW95117 EAW95118 Q8IU57 AF439325 AAN63632 AJ534330 CAD58829 AJ534331 CAD58830 AK160364 BAD18707 AY129151 AAN28266 AY129152 AAN28267 AY129153 AAN28268 BC101407 BC101408 AAI01409 BC101975 AAI01976 BC139722 AAI39723 BC140872 AAI40873 CN289861 JN591376 AEX60805 XM_006710394 XP_006710457 NM_170743 NP_734464 NM_173064 NP_775087 NM_173065 NP_775088
Function	The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210, ECO:0000269|PubMed:12521379}.
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Interleukin-28 receptor subunit alpha (IL28RA), Human, ELISA Kit - CSB-EL011647HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

LEGEND MAX™ Human IL-28A ELISA Kit with Pre-coated Plates - 435507 from Biolegend Category ELISA Kit Prices $395.00, $1,395.00 Sizes 1 pre-coated plate, 5 pre-coated plates Sensitivity 1 pg/mL Range 15.6-1,000 pg/mL

Interleukin 12 Receptor (IL-12R), ELISA Kit - MBS260611 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Up to 0.06 ng/ml. Range 20 ng/ml-0.312 ng/ml

Interleukin 12 Receptor (IL-12R), ELISA Kit - MBS261411 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor (IL-12R), ELISA Kit - MBS261170 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.06 ng/ml. Range 20 ng/ml-0.312 ng/ml

Interleukin 12 Receptor (IL-12R), ELISA Kit - MBS267895 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor (IL-12R), ELISA Kit - MBS266619 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor (IL-12R), ELISA Kit - MBS2600112 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor (IL-12R), ELISA Kit - MBS262347 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor (IL-12R), ELISA Kit - MBS262109 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS065545 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS076305 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS098333 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS105515 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS073529 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS085830 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS082519 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS056413 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS050049 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS090757 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS085915 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS057246 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS055728 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS085938 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 12 Receptor Beta 1, ELISA Kit - MBS091065 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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