IFNLR1
| Gene Symbol | IFNLR1 |
|---|---|
| Entrez Gene | 163702 |
| Alt Symbol | CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon, lambda receptor 1 |
| Other Description | CRF2-12|IFN-lambda receptor 1|IFN-lambda-R1|IL-28 receptor subunit alpha|IL-28R-alpha|IL-28RA|class II cytokine receptor CRF2/12|cytokine receptor class-II member 12|cytokine receptor family 2 member 12|interferon lambda receptor 1|interferon lambda, receptor 1|interleukin 28 alpha receptor|interleukin 28 receptor A|interleukin 28 receptor, alpha (interferon, lambda receptor)|interleukin or cytokine receptor 2|interleukin-28 receptor subunit alpha|likely interleukin or cytokine receptor 2 |
| Swissprots | Q5VTX7 Q5VTX5 Q6ZML8 Q8IZI7 Q5VTX8 Q8IV66 Q8IU57 Q8IZI8 |
| Accessions | CAJ41832 CAV33829 EAW95113 EAW95114 EAW95115 EAW95116 EAW95117 EAW95118 Q8IU57 AF439325 AAN63632 AJ534330 CAD58829 AJ534331 CAD58830 AK160364 BAD18707 AY129151 AAN28266 AY129152 AAN28267 AY129153 AAN28268 BC101407 BC101408 AAI01409 BC101975 AAI01976 BC139722 AAI39723 BC140872 AAI40873 CN289861 JN591376 AEX60805 XM_006710394 XP_006710457 NM_170743 NP_734464 NM_173064 NP_775087 NM_173065 NP_775088 |
| Function | The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210, ECO:0000269|PubMed:12521379}. |
| Subcellular Location | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
IL-28R CRISPR/Cas9 KO Plasmid (h) - sc-402530 from Santa Cruz Biotechnology
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IL-28R HDR Plasmid (h) - sc-402530-HDR from Santa Cruz Biotechnology
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IL-28R Double Nickase Plasmid (h) - sc-402530-NIC from Santa Cruz Biotechnology
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IL-28R Double Nickase Plasmid (h2) - sc-402530-NIC-2 from Santa Cruz Biotechnology
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IL-28R CRISPR Activation Plasmid (h) - sc-402530-ACT from Santa Cruz Biotechnology
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IL-28R CRISPR Activation Plasmid (h2) - sc-402530-ACT-2 from Santa Cruz Biotechnology
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IL-28R Lentiviral Activation Particles (h) - sc-402530-LAC from Santa Cruz Biotechnology
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IL-28R Lentiviral Activation Particles (h2) - sc-402530-LAC-2 from Santa Cruz Biotechnology
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IL-28R siRNA (h) - sc-62497 from Santa Cruz Biotechnology
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IL-28R shRNA Plasmid (h) - sc-62497-SH from Santa Cruz Biotechnology
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IL-28R shRNA (h) Lentiviral Particles - sc-62497-V from Santa Cruz Biotechnology
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IL-28 R alpha/IFN-lambda R1 RNAi - H00163702-R05 from Novus Biologicals
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IL-28 R alpha/IFN-lambda R1 RNAi - H00163702-R04 from Novus Biologicals
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IL-28 R alpha/IFN-lambda R1 RNAi - H00163702-R06 from Novus Biologicals
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MISSION® esiRNA - EHU065311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10621 from Sigma-Aldrich
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IFNLR1 siRNA (Human) - CRJ5996 from Cohesion Biosciences
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IFNLR1 - MBS8214730 from MyBioSource
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shRNA set against Human Il28ra (NM_173065.2) - SHH318837 from Creative biogene
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Human IFNLR1 siRNA - orb276497 from Biorbyt
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IFNLR1 shRNA Plasmid (Human) - CHJ5996 from Cohesion Biosciences
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IL28RA miRNA 3'UTR clone - MiUTR4H-TG04505 from Creative biogene
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