IFNLR1

Gene Symbol	IFNLR1
Entrez Gene	163702
Alt Symbol	CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2
Species	Human
Gene Type	protein-coding
Description	interferon, lambda receptor 1
Other Description	CRF2-12|IFN-lambda receptor 1|IFN-lambda-R1|IL-28 receptor subunit alpha|IL-28R-alpha|IL-28RA|class II cytokine receptor CRF2/12|cytokine receptor class-II member 12|cytokine receptor family 2 member 12|interferon lambda receptor 1|interferon lambda, receptor 1|interleukin 28 alpha receptor|interleukin 28 receptor A|interleukin 28 receptor, alpha (interferon, lambda receptor)|interleukin or cytokine receptor 2|interleukin-28 receptor subunit alpha|likely interleukin or cytokine receptor 2
Swissprots	Q5VTX7 Q5VTX5 Q6ZML8 Q8IZI7 Q5VTX8 Q8IV66 Q8IU57 Q8IZI8
Accessions	CAJ41832 CAV33829 EAW95113 EAW95114 EAW95115 EAW95116 EAW95117 EAW95118 Q8IU57 AF439325 AAN63632 AJ534330 CAD58829 AJ534331 CAD58830 AK160364 BAD18707 AY129151 AAN28266 AY129152 AAN28267 AY129153 AAN28268 BC101407 BC101408 AAI01409 BC101975 AAI01976 BC139722 AAI39723 BC140872 AAI40873 CN289861 JN591376 AEX60805 XM_006710394 XP_006710457 NM_170743 NP_734464 NM_173064 NP_775087 NM_173065 NP_775088
Function	The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210, ECO:0000269|PubMed:12521379}.
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL28 Receptor alpha protein fragment - ab165762 from Abcam Category Protein Source Wheat germ Species Human

CRF2-12 / IL28RA Antibody Blocking Peptide - LS-E17394 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IL-28 R alpha/IFN-lambda R1 Protein - H00163702-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human IL-28 R alpha/IFN-lambda R1 Fc Chimera, CF - 5260-MR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

IL28R alpha Blocking Peptide - 33R-7511 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

IL28R alpha Blocking Peptide - 33R-2338 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

IL-28RA Blocking Peptide - abx064079 from Abbexa Category Peptide Species Human

IL28RA - H00163702-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IL28RA - H00163702-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IL28RA fusion protein - Ag18830 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

IL28RA fusion protein - ag18609 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Interleukin 28 Receptor, Alpha (interferon, lambda receptor), Fc-tagged - IL28RA-5659H from Creative Biomart Category Protein Source Murine myeloma cellline, NS0-derived.

Recombinant Human IL28RA - IL28RA-841H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Interleukin 28 Receptor, Alpha (interferon, lambda receptor) - IL28RA-601H from Creative Biomart Category Protein Source E. coli Species Human

HumanKine® IL-28B, Human Recombinant Xeno-Free - GF426 from EMD Millipore Prices $261.00 Sizes 10 µg Source HumanKine growth factors are expressed in a proprietary human 293 protein expression system and are manufactured without the use of any animal products and are considered Xeno-Free. Species Human

IL-28RA Blocking Peptide - CBP2885 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Recombinant Human Interleukin-28 receptor subunit alpha(IL28RA) - CSB-YP816871HU CSB-EP816871HU CSB-BP816871HU CSB-MP816871HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human IL-28 R alpha/IFN-lambda R1 Fc Chimera, CF - 5260-MR from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Human IL-28 R alpha (Arg21 - Ala228) Accession # Q8IU57 IEGRMD Human IgG 1 (Pro100 - Lys330) N-terminus C-terminus Species Human

Recombinant Human IL-28A/IFN-lambda 2 - CRI008B from Cell Science Prices $695.00 Sizes 25 μg Species Human

IL-28 R alpha/IFN-lambda R1 Recombinant Protein Antigen - NBP1-84381PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

IL28RA-Blocking-Peptide-C-term - BP20138b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IL28RA-Blocking-Peptide-Center - BP21372c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IL28RA Peptide, Human - M34GP07588H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Interleukin-28 receptor subunit alpha(IFNLR1),partial - CSB-EP816871HU1 from Cusabio Category Protein Source E.coli Species Human

Interleukin-28 receptor subunit alpha (IL28RA), Recombinant Protein - MBS1279766 from MyBioSource Category Protein Prices $960.00, $960.00, $1,180.00, $1,180.00, $1,435.00, $1,435.00, $1,900.00, $1,900.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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