Gene Symbol | BCKDK |
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Entrez Gene | 10295 |
Alt Symbol | BCKDKD, BDK |
Species | Human |
Gene Type | protein-coding |
Description | branched chain ketoacid dehydrogenase kinase |
Other Description | BCKD-kinase|BCKDHKIN|[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial|branched chain alpha-ketoacid dehydrogenase kinase |
Swissprots | Q96G95 A8MY43 Q96IN5 Q6FGL4 O14874 |
Accessions | EAW52160 EAW52161 EAW52162 EAW52163 EAW52164 O14874 AF026548 AAB82714 AK130145 AK294691 BAG57850 BC007363 AAH07363 BC009872 AAH09872 BM679327 BX427330 CR542093 CAG46890 DQ893687 ABM84613 DQ896864 ABM87863 NM_001122957 NP_001116429 NM_001271926 NP_001258855 NM_005881 NP_005872 |
Function | Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. {ECO:0000269|PubMed:24449431}. |
Subcellular Location | Mitochondrion matrix. Mitochondrion {ECO:0000269|PubMed:24449431}. |
Tissue Specificity | Ubiquitous. |
BCKDK CRISPR/Cas9 KO Plasmid (h) - sc-411451 from Santa Cruz Biotechnology
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BCKDK HDR Plasmid (h) - sc-411451-HDR from Santa Cruz Biotechnology
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BCKDK Double Nickase Plasmid (h) - sc-411451-NIC from Santa Cruz Biotechnology
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BCKDK Double Nickase Plasmid (h2) - sc-411451-NIC-2 from Santa Cruz Biotechnology
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BCKDK CRISPR Activation Plasmid (h) - sc-411451-ACT from Santa Cruz Biotechnology
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BCKDK CRISPR Activation Plasmid (h2) - sc-411451-ACT-2 from Santa Cruz Biotechnology
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BCKDK Lentiviral Activation Particles (h) - sc-411451-LAC from Santa Cruz Biotechnology
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BCKDK Lentiviral Activation Particles (h2) - sc-411451-LAC-2 from Santa Cruz Biotechnology
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BCKDK siRNA (h) - sc-93313 from Santa Cruz Biotechnology
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BCKDK shRNA Plasmid (h) - sc-93313-SH from Santa Cruz Biotechnology
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BCKDK shRNA (h) Lentiviral Particles - sc-93313-V from Santa Cruz Biotechnology
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BCKDK RNAi - H00010295-R02 from Novus Biologicals
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MISSION® esiRNA - EHU086441 from Sigma-Aldrich
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MISSION® siRNA - SIHK0156 from Sigma-Aldrich
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MISSION® siRNA - SIHK0160 from Sigma-Aldrich
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MISSION® siRNA - SIHK0155 from Sigma-Aldrich
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MISSION® siRNA - SIHK0159 from Sigma-Aldrich
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MISSION® siRNA - SIHK0158 from Sigma-Aldrich
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MISSION® siRNA - SIHK0157 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3903 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3903 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02401 from Sigma-Aldrich
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BCKDK siRNA (Human) - CRH6975 from Cohesion Biosciences
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BCKDK - MBS8213449 from MyBioSource
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BCKDK shRNA Plasmid (Human) - CHH6975 from Cohesion Biosciences
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