KLHL20

Gene Symbol	KLHL20
Entrez Gene	27252
Alt Symbol	KHLHX, KLEIP, KLHLX
Species	Human
Gene Type	protein-coding
Description	kelch-like family member 20
Other Description	Kelch motif containing protein|kelch-like 20|kelch-like ECT2 interacting protein|kelch-like ECT2-interacting protein|kelch-like protein 20|kelch-like protein X
Swissprots	Q5TZF2 Q9Y2M5 Q9H457 B4DUR0 B3KMA0 Q5ZF45
Accessions	EAW90952 EAW90953 EAW90954 EAW90955 Q9Y2M5 AB026190 BAA77027 AJ844466 CAH59617 AK001430 BAG50912 AK300755 BAG62422 AK308048 BC005253 AAH05253 BC063418 AAH63418 CB143306 XM_005245093 XP_005245150 XM_011509420 XP_011507722 XR_921766 XR_921767 NM_014458 NP_055273
Function	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'- linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubM
Subcellular Location	Cytoplasm, perinuclear region. Nucleus. Golgi apparatus, trans-Golgi network. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination (PubMed:20389280). {ECO:0000269|PubMed:20389280}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KLHL20 (K-12) - sc-160475 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

KLHL20 (S-14) - sc-160477 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-KLHL20 antibody - ab67682 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-KLHL20 Antibody (aa481-530) - LS-C117149 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KLHL20 Antibody - LS-C332557 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KLHL20 Antibody - LS-C308664 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

KLHL20 Antibody - NBP1-81559 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

KLHL20 Antibody - NBP1-79570 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

KLHL20 Antibody - NBP2-38708 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

KLHL20 Antibody - H00027252-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

KLHL20 Polyclonal Antibody - bs-7515R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KLHL20 antibody produced in mouse - SAB1407350 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-KLHL20 antibody produced in rabbit - SAB2701606 from Sigma-Aldrich Prices $326.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KLHL20 antibody produced in rabbit - HPA025034 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

KLHL20 antibody - C-terminal region (ARP55062_P050) - ARP55062_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

klhl20 antibody - zf125156 from GeneTex Host Rabbit Clonality Polyclonal

KLHL20 antibody - GTX118945 from GeneTex Host Rabbit Clonality Polyclonal

Anti -KLHL20 (KLEIP, Kelch-like Protein 20, Kelch-like ECT2-interacting Protein,Kelch-like Protein X, KHLHX, KLHLX, RP3-383J4.3) - 128870 from USBiological Life Science Host Mouse Clonality Polyclonal

Anti -KLHL20 (Kelch-like protein 20, Kelch-like ECT2-interacting protein, Kelch-likeprotein X, KHLHX, KLEIP, KLHLX) - 211667 from USBiological Life Science Host Rabbit Clonality Polyclonal

KLHL20 Polyclonal Antibody - A3418 from ABclonal Prices $200.00, $480.00 Sizes 50 µg, 200 µg Host Rabbit Clonality Polyclonal

KLHL20 antibody - 70R-18152 from Fitzgerald Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

KLHL20 antibody - 70R-9302 from Fitzgerald Prices $345.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

KLHL20 Antibody - abx002452 from Abbexa Host Rabbit Clonality Polyclonal

Kelch-like protein 20 antibody - 18111-1-AP from Acris Antibodies Prices $270.00 Sizes 150 µl Host Rabbit Clonality Polyclonal

Kelch-like protein 20 antibody - H00027252-B01P from Acris Antibodies Prices $360.00 Sizes 50 µg Host Mouse Clonality Polyclonal

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