| Gene Symbol |
KLHL20
|
| Entrez Gene |
27252
|
| Alt Symbol |
KHLHX, KLEIP, KLHLX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kelch-like family member 20
|
| Other Description |
Kelch motif containing protein|kelch-like 20|kelch-like ECT2 interacting protein|kelch-like ECT2-interacting protein|kelch-like protein 20|kelch-like protein X
|
| Swissprots |
Q5TZF2 Q9Y2M5 Q9H457 B4DUR0 B3KMA0 Q5ZF45
|
| Accessions |
EAW90952 EAW90953 EAW90954 EAW90955 Q9Y2M5 AB026190 BAA77027 AJ844466 CAH59617 AK001430 BAG50912 AK300755 BAG62422 AK308048 BC005253 AAH05253 BC063418 AAH63418 CB143306 XM_005245093 XP_005245150 XM_011509420 XP_011507722 XR_921766 XR_921767 NM_014458 NP_055273
|
| Function |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'- linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubM
|
| Subcellular Location |
Cytoplasm, perinuclear region. Nucleus. Golgi apparatus, trans-Golgi network. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination (PubMed:20389280). {ECO:0000269|PubMed:20389280}.
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