| Gene Symbol |
E2F6
|
| Entrez Gene |
1876
|
| Alt Symbol |
E2F-6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E2F transcription factor 6
|
| Other Description |
transcription factor E2F6
|
| Swissprots |
Q7Z2H6 Q6Q9Z6 O60544 G5E936 A8K2Z8 O75461 Q53QY9
|
| Accessions |
AAM10784 AAM10785 AAT02635 AAY14826 CAD37950 CAD37951 CAD37952 EAX00931 EAX00932 EAX00933 EAX00934 EAX00935 EAX00936 O75461 AF041381 AAC14694 AF059292 AAC31426 AF088059 AK096197 BAG53228 AK223159 BAD96879 AK223407 BAD97127 AK290413 BAF83102 AK293504 BAH11524 AU132447 AU142999 AY083996 AAM10783 AY551346 AAT02636 AY551347 AAT02637 AY551348 AAT02638 AY551349 AAT02639 AY551350 AAT02640 AY551351 AAT02641 BC008348 AAH08348 BC062610 BC107740 AAI07741 BI772069 BQ447956 BU076470 DA609616 XM_011510317 XP_011508619 NM_001278275 NP_001265204 NM_001278276 NP_001265205 NM_001278277 NP_001265206 NM_001278278 NP_001265207 NM_198256 NP_937987 NM_212540 NP_997705 NR_103490 NM_198257 NM_198258 NM_198325
|
| Function |
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.
|