E2F6

Gene Symbol E2F6
Entrez Gene 1876
Alt Symbol E2F-6
Species Human
Gene Type protein-coding
Description E2F transcription factor 6
Other Description transcription factor E2F6
Swissprots Q7Z2H6 Q6Q9Z6 O60544 G5E936 A8K2Z8 O75461 Q53QY9
Accessions AAM10784 AAM10785 AAT02635 AAY14826 CAD37950 CAD37951 CAD37952 EAX00931 EAX00932 EAX00933 EAX00934 EAX00935 EAX00936 O75461 AF041381 AAC14694 AF059292 AAC31426 AF088059 AK096197 BAG53228 AK223159 BAD96879 AK223407 BAD97127 AK290413 BAF83102 AK293504 BAH11524 AU132447 AU142999 AY083996 AAM10783 AY551346 AAT02636 AY551347 AAT02637 AY551348 AAT02638 AY551349 AAT02639 AY551350 AAT02640 AY551351 AAT02641 BC008348 AAH08348 BC062610 BC107740 AAI07741 BI772069 BQ447956 BU076470 DA609616 XM_011510317 XP_011508619 NM_001278275 NP_001265204 NM_001278276 NP_001265205 NM_001278277 NP_001265206 NM_001278278 NP_001265207 NM_198256 NP_937987 NM_212540 NP_997705 NR_103490 NM_198257 NM_198258 NM_198325
Function Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Subcellular Location Nucleus.
Tissue Specificity Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.

E2F-6 (C-10) - sc-398662 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-6 (C-10): sc-398662. Western blot analysis of E2F-6 expression in K-562 (A), Jurkat (B) and HeLa (C) nuclear extracts and Hep G2 whole cell lysate (D).

E2F-6 (E-3) - sc-398677 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-6 (E-3): sc-398677. Western blot analysis of expression in K-562 (A), Jurkat (B) and HeLa (C) nuclear extracts and Hep G2 whole cell lysate (D).

E2F-6 (H-50) - sc-22823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
E2F-6 (H-50): sc-22823. Western blot analysis of E2F-6 expression in K-562 nuclear extract.

E2F-6 (E-20) - sc-8366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

E2F-6 (K-20) - sc-8176 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

E2F-6 (TFE61) - sc-53273 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
E2F-6 (TFE61): sc-53273. Western blot analysis of E2F-6 expression in K-562 (A), Jurkat (B) and HeLa (C) nuclear extracts.

E2F-6 (N-19) - sc-8175 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-E2F6 antibody - ab152151 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-E2F6 antibody (ab152151) at 1/1000 dilution + A549 whole cell lysate at 30 µg

Anti-E2F6 antibody - ab66609 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-E2F6 antibody (ab66609) at 1.25 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-E2F6 antibody - ab99456 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-E2F6 antibody (ab99456) at 1 µg/ml + Human skeletal muscle lysate, in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-E2F6 antibody [EPR11201] - ab155978 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11201
All lanes : Anti-E2F6 antibody [EPR11201] (ab155978) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : K562 cell lysateLane 3 : HeLa cell lysateLane 4 : A549 cell lysateLane 5 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-E2F6 antibody [TFE61] - ab11952 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TFE61

Anti-E2F6 antibody - ChIP Grade - ab53061 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E2F6 antibody - ChIP Grade (ab53061) at 1/500 dilutionLane 1 : Extracts of HepG2 cellsLane 2 : Extracts of HepG2 cells treated with peptide

Anti-E2F6 antibody - N-terminal - ab176368 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-E2F6 antibody - N-terminal (ab176368) at 1/1000 dilution + Mouse brain total cell extracts

E2F6 Antibody (1F7-A9) - H00001876-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F7-A9
Western Blot: E2F6 Antibody (1F7-A9) [H00001876-M02] - Western Blot analysis of E2F6 expression in A-549 ( Cat # L025V1 ).

E2F6 Antibody - NBP2-14936 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: E2F6 Antibody [NBP2-14936] - Sample (30 ug of whole cell lysate) A: A549 12% SDS PAGE E2F6 antibody, antibody diluted at 1:1000.

E2F6 Antibody - NB100-91739 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: E2F6 Antibody [NB100-91739] - Extracts from HepG2 cells.

E2F6 Antibody - H00001876-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: E2F6 Antibody [H00001876-B01] - analysis of E2F6 expression in transfected 293T cell line by E2F6 MaxPab polyclonal antibody (B01). Lane 1: E2F6 transfected lysate (31.80 KDa). Lane 2: Non-transfected lysate.

E2F6 Antibody - NBP1-46117 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

E2F6 Antibody - H00001876-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: E2F6 Antibody [H00001876-D01P] - analysis of E2F6 expression in transfected 293T cell line by E2F6 MaxPab rabbit polyclonal antibody. Lane 1: E2F6 transfected lysate (31.80 KDa). Lane 2: Non-transfected lysate.

E2F-4 Antibody (2B6-G9) - H00001876-M01 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 2B6-G9

E2F6 Antibody - NBP1-67549 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: E2F6 Antibody [NBP1-67549] - Analysis of extracts from HepG2 cells, using E2F6 Antibody. The lane on the right is treated with the synthesized peptide.

E2F6 Polyclonal Antibody - bs-1750R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-E2F6 antibody produced in mouse - E1532 from Sigma-Aldrich

Prices $63.50, $413.50
Sizes 25 µl, 200 µl
Host Mouse
Clonality Monoclonal
Clone TFE61
<B>Immunoblotting</B><BR/>Nuclear extract of HeLa cells was separated on SDS-PAGE and incubated with serial concentrations of Monoclonal Anti-E2F6 (<B>Cat. No. E1532</B>). The antibody was developed with Goat Anti-Mouse IgG, Peroxidase conjugate (<B>Cat. No. A2304</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. 0.25 μg/mL antibody<BR/>2. 0.5 μg/mL antibody<BR/>3. 1 μg/mL antibody<BR/>4. 2 μg/mL antibody<BR/>5. 4 μg/mL antibody<BR/>6. 8 μg/mL antibody<BR/>7. negative control

Anti-E2F6 antibody produced in rabbit - AV32221 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-E2F6: <B>Cat. No. AV32221</B>: Immunohistochemistry of E2F6 in Human Lung tissue with E2F6 antibody at 4-8 μg/mL.
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