Gene Symbol | CACNG8 |
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Entrez Gene | 59283 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | calcium channel, voltage-dependent, gamma subunit 8 |
Other Description | TARP gamma-8|neuronal voltage-gated calcium channel gamma-8 subunit|transmembrane AMPAR regulatory protein gamma-8|voltage-dependent calcium channel gamma-8 subunit |
Swissprots | Q9BXT0 Q8WXS5 Q9BY23 |
Accessions | EAW72168 Q8WXS5 AF234892 AAK15019 AF288388 AAK20031 AF361354 AAL50049 AK055160 AK131287 BC157119 AAI57120 BC172268 AAI72268 NM_031895 NP_114101 |
Function | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}. |
Subcellular Location | Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. |
Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
L-type Ca ++ CP γ8 (A-8) - sc-514421 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ8 (C-12) - sc-168395 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ8 (E-13) - sc-168396 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ8 (S-13) - sc-168397 from Santa Cruz Biotechnology
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Anti-CACNG8 antibody - ab85880 from Abcam
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Anti-CACNG8 antibody - ab116142 from Abcam
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Anti-CACNG8 Antibody (aa90-119) IHC-plus⢠- LS-B9612 from LifeSpan Bioscience
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Anti-CACNG8 Antibody (Internal) - LS-C94077 from LifeSpan Bioscience
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Anti-CACNG8 Antibody (aa97-127, AP) - LS-C233346 from LifeSpan Bioscience
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Anti-CACNG8 Antibody (aa97-127, Biotin) - LS-C233348 from LifeSpan Bioscience
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Anti-CACNG8 Antibody (aa97-127, APC) - LS-C233347 from LifeSpan Bioscience
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Anti-CACNG8 Antibody (aa97-127, FITC) - LS-C233349 from LifeSpan Bioscience
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Anti-CACNG8 Antibody (aa180-229) - LS-C145588 from LifeSpan Bioscience
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Anti-CACNG8 Antibody (aa97-127, Azide-free, HRP) - LS-C249566 from LifeSpan Bioscience
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Anti-CACNG8 Antibody (aa97-127, PE) - LS-C233352 from LifeSpan Bioscience
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Anti-CACNG8 Antibody (aa97-127) - LS-C319982 from LifeSpan Bioscience
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CACNG8 Antibody - NBP1-20124 from Novus Biologicals
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CACNG8 Antibody - NBP1-30701 from Novus Biologicals
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Anti-CACNG8 antibody produced in rabbit - HPA041351 from Sigma-Aldrich
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ANTI-CACNG8 (N-TERM) antibody produced in rabbit - SAB1303452 from Sigma-Aldrich
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CACNG8-Antibody-N-term - AP11619a from Abgent, a WuXi AppTec company
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CACNG8 Antibody - N-terminal region (OAAB07865) - OAAB07865 from Aviva Systems Biology
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Cacng8 antibody - 70R-8073 from Fitzgerald
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CACNG8 (N-term) antibody - AP50709PU-N from Acris Antibodies
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CACNG8, Polyclonal Antibody - MBS642838 from MyBioSource
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