| Gene Symbol |
CACNG8
|
| Entrez Gene |
59283
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, gamma subunit 8
|
| Other Description |
TARP gamma-8|neuronal voltage-gated calcium channel gamma-8 subunit|transmembrane AMPAR regulatory protein gamma-8|voltage-dependent calcium channel gamma-8 subunit
|
| Swissprots |
Q9BXT0 Q8WXS5 Q9BY23
|
| Accessions |
EAW72168 Q8WXS5 AF234892 AAK15019 AF288388 AAK20031 AF361354 AAL50049 AK055160 AK131287 BC157119 AAI57120 BC172268 AAI72268 NM_031895 NP_114101
|
| Function |
Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}.
|
| Top Pathways |
MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy
|