| Gene Symbol |
CD164
|
| Entrez Gene |
8763
|
| Alt Symbol |
MGC-24, MUC-24, endolyn
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD164 molecule, sialomucin
|
| Other Description |
CD164 antigen, sialomucin|CD164 variant C|MGC-24v|multi-glycosylated core protein 24|sialomucin core protein 24
|
| Swissprots |
Q9BPV0 O95413 Q9NR26 E1P5E9 Q04900 E1P5E7 Q5JSU6 B4DQ85 E1P5E8
|
| Accessions |
AAG53903 AAG53904 AAG53905 CDM22287 EAW48348 EAW48349 EAW48350 EAW48351 EAW48352 EAW48353 EAW48354 EAW48355 Q04900 AF106518 AAC82473 AF263279 AAF85965 AF299341 AAG53906 AF299342 AAG53907 AF299343 AAG53908 AK298684 BAG60847 AK301692 BAG63164 AK303525 BAG64553 AK307193 AK308664 AK310854 AK312357 BAG35275 AK315908 BAH14279 BC011522 AAH11522 BC037914 BC040317 BM668503 BM817924 BM830140 D14043 BAA03130 DC403839 DQ891034 ABM81960 DQ894213 ABM85139 EB388947 FJ200494 ACO54891 NM_001142401 NP_001135873 NM_001142402 NP_001135874 NM_001142403 NP_001135875 NM_001142404 NP_001135876 NM_006016 NP_006007
|
| Function |
Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Lysosome membrane {ECO:0000269|PubMed:11027692}; Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}. Endosome membrane {ECO:0000269|PubMed:11027692}; Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}. Cell membrane {ECO:0000269|PubMed:11027692}; Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}.
|
| Tissue Specificity |
Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells. {ECO:0000269|PubMed:10878358, ECO:0000269|PubMed:11027692, ECO:0000269|PubMed:1478919, ECO:0000269|PubMed:16859559, ECO:0000269|PubMed:9763543}.
|
| Top Pathways |
Lysosome
|