PIK3CG

Gene Symbol	PIK3CG
Entrez Gene	5294
Alt Symbol	PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Other Description	1-phosphatidylinositol 3-kinase|PI3-kinase subunit gamma|phosphatidylinositol 3 kinase gamma, p110 gamma|phosphatidylinositol 3-kinase catalytic 110-kD gamma|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphoinositide-3-kinase gamma catalytic subunit|ptdIns-3-kinase subunit gamma|ptdIns-3-kinase subunit p110-gamma|serine/threonine protein kinase PIK3CG
Swissprots	Q8IV23 Q9BZC8 A4D0Q6 P48736
Accessions	AAQ96873 CCO13788 EAL24396 EAW83387 EAW83388 EAW83389 P48736 AA810265 AF327656 AAG61115 AK292684 BAF85373 AK313753 AY496423 AAS75801 BC035683 AAH35683 BX648341 X83368 CAA58284 XM_005250443 XP_005250500 XM_011516316 XP_011514618 XM_011516317 XP_011514619 NM_001282426 NP_001269355 NM_001282427 NP_001269356 NM_002649 NP_002640
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin- based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12163475}. Cell membrane {ECO:0000269|PubMed:12163475}.
Tissue Specificity	Pancreas, skeletal muscle, liver and heart. {ECO:0000269|PubMed:7624799}.
Top Pathways	Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG), Human, ELISA Kit - E01P0849 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, ELISA Kit - MBS281435 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

PI3K, ELISA Kit - MBS2513184 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

PI3K, ELISA Kit - MBS2513464 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

PI3K, ELISA Kit - MBS2514744 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

PI3K, ELISA Kit - MBS2505796 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Rat PI3K is 46.875pg/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 78.125-5000pg/mL

PI3K, ELISA Kit - MBS2507349 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

PI3K, ELISA Kit - MBS2508186 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.875pg/mL Range 78.125-5000pg/mL

PI3K, ELISA Kit - MBS2504892 from MyBioSource Category ELISA Kit Prices $430.00, $520.00 Sizes 48 strip wells, 96 strip wells

PI3K, ELISA Kit - MBS2507759 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Porcine PI3K is 0.188ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.313-20ng/mL

PI3K, ELISA Kit - MBS2505972 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

Human PIK3CG ELISA Kit - E028970 from Biobool Category ELISA Kit

anti-PIK3CG antibody - ARG57472 from Arigo Biolaboratories Category ELISA Kit

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