PIK3CG

Gene Symbol	PIK3CG
Entrez Gene	5294
Alt Symbol	PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Other Description	1-phosphatidylinositol 3-kinase|PI3-kinase subunit gamma|phosphatidylinositol 3 kinase gamma, p110 gamma|phosphatidylinositol 3-kinase catalytic 110-kD gamma|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphoinositide-3-kinase gamma catalytic subunit|ptdIns-3-kinase subunit gamma|ptdIns-3-kinase subunit p110-gamma|serine/threonine protein kinase PIK3CG
Swissprots	Q8IV23 Q9BZC8 A4D0Q6 P48736
Accessions	AAQ96873 CCO13788 EAL24396 EAW83387 EAW83388 EAW83389 P48736 AA810265 AF327656 AAG61115 AK292684 BAF85373 AK313753 AY496423 AAS75801 BC035683 AAH35683 BX648341 X83368 CAA58284 XM_005250443 XP_005250500 XM_011516316 XP_011514618 XM_011516317 XP_011514619 NM_001282426 NP_001269355 NM_001282427 NP_001269356 NM_002649 NP_002640
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin- based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12163475}. Cell membrane {ECO:0000269|PubMed:12163475}.
Tissue Specificity	Pancreas, skeletal muscle, liver and heart. {ECO:0000269|PubMed:7624799}.
Top Pathways	Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PI 3 Kinase catalytic subunit gamma full length protein - ab125538 from Abcam Category Protein Prices $192.00, $1,845.00 Sizes 5 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Active human PI 3 Kinase catalytic subunit gamma full length protein - ab157600 from Abcam Category Protein Prices $465.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PI 3 Kinase catalytic subunit gamma (mutated D946 A) full length protein - ab91392 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human PI 3 Kinase catalytic subunit gamma peptide - ab22948 from Abcam Category Peptide Species Human

PIK3CG / PI3K Gamma Antibody Blocking Peptide - LS-E25416 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3CG / PI3K Gamma Antibody Blocking Peptide - LS-E7390 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3CG / PI3K Gamma Antibody Blocking Peptide - LS-E9431 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3CG / PI3K Gamma Antibody Blocking Peptide - LS-E9559 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3CG / PI3K Gamma Antibody Blocking Peptide - LS-E9560 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PI 3-Kinase p110 gamma Peptide - P1598 from Novus Biologicals Category Peptide Species Human

PI 3-Kinase p110 gamma Peptide - P2997 from Novus Biologicals Category Peptide Species Human

PI 3-Kinase p110 gamma Peptide - P2996 from Novus Biologicals Category Peptide Species Human

PI 3-Kinase p110 gamma Peptide - P3230 from Novus Biologicals Category Peptide Species Human

PI 3-Kinase p110 gamma Peptide - P3229 from Novus Biologicals Category Peptide Species Human

Phospho-PIK3CGS1100-Antibody-Blocking-peptide - BP3464a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

PI3KCG-Antibody-C-term-Blocking-Peptide - BP8021b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3KCG-Antibody-N-term-Blocking-Peptide - BP8021a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIK3CG-Antibody-S1100-Blocking-Peptide - BP8180d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3KCG-Antibody-Center-Blocking-Peptide - BP8180c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIK3CG blocking peptide - GTX89900-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog

Pi 3 Kinase Catalytic Subunit gamma Peptide - AC21-0244-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PIK3CG Peptide - 45-111P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

PI3 kinase (p120g/PIK3R5), Human Recombinant Protein complex - GWB-PSDBD1 from Genway Biotech Category Protein Prices $584.00 Sizes 20 µg Species Human

PI3 kinase (p120g), Active Human Recombinant Protein - GWB-24632F from Genway Biotech Category Protein Prices $584.00 Sizes 20 µg Species Human

Recombinant Human PIK3CG, His-tagged - PIK3CG-53H from Creative Biomart Category Protein Source Sf9 insect cells .

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