PIK3CG

Gene Symbol	PIK3CG
Entrez Gene	5294
Alt Symbol	PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Other Description	1-phosphatidylinositol 3-kinase|PI3-kinase subunit gamma|phosphatidylinositol 3 kinase gamma, p110 gamma|phosphatidylinositol 3-kinase catalytic 110-kD gamma|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphoinositide-3-kinase gamma catalytic subunit|ptdIns-3-kinase subunit gamma|ptdIns-3-kinase subunit p110-gamma|serine/threonine protein kinase PIK3CG
Swissprots	Q8IV23 Q9BZC8 A4D0Q6 P48736
Accessions	AAQ96873 CCO13788 EAL24396 EAW83387 EAW83388 EAW83389 P48736 AA810265 AF327656 AAG61115 AK292684 BAF85373 AK313753 AY496423 AAS75801 BC035683 AAH35683 BX648341 X83368 CAA58284 XM_005250443 XP_005250500 XM_011516316 XP_011514618 XM_011516317 XP_011514619 NM_001282426 NP_001269355 NM_001282427 NP_001269356 NM_002649 NP_002640
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin- based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12163475}. Cell membrane {ECO:0000269|PubMed:12163475}.
Tissue Specificity	Pancreas, skeletal muscle, liver and heart. {ECO:0000269|PubMed:7624799}.
Top Pathways	Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PI 3-kinase p110γ CRISPR/Cas9 KO Plasmid (h) - sc-401043 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PI 3-kinase p110γ HDR Plasmid (h) - sc-401043-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PI 3-kinase p110γ Double Nickase Plasmid (h) - sc-401043-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PI 3-kinase p110γ Double Nickase Plasmid (h2) - sc-401043-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PI 3-kinase p110γ CRISPR Activation Plasmid (h) - sc-401043-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PI 3-kinase p110γ CRISPR Activation Plasmid (h2) - sc-401043-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PI 3-kinase p110γ Lentiviral Activation Particles (h) - sc-401043-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PI 3-kinase p110γ Lentiviral Activation Particles (h2) - sc-401043-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PI 3-kinase p110γ siRNA (h) - sc-39129 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PI 3-kinase p110γ shRNA Plasmid (h) - sc-39129-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PI 3-kinase p110γ shRNA (h) Lentiviral Particles - sc-39129-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU081631 from Sigma-Aldrich Category siRNA

MISSION® siRNA - SIHK1661 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1663 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1662 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2103 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2103 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PIK3CG siRNA (Human) - CRH3539 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PI 3-Kinase p110 gamma RNAi - H00005294-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human PIK3CG (NM_002649.2) - SHH375748 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PIK3CG(NM_002649.2) - SHR104890 from Creative biogene Category siRNA Species Reactivities Human

Human PIK3CG siRNA - orb264041 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PIK3CG shRNA Plasmid (Human) - CHH3539 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PIK3CG miRNA 3'UTR clone - MiUTR1H-07908 from Creative biogene Species Reactivities Human

Search more