| Gene Symbol |
SETMAR
|
| Entrez Gene |
6419
|
| Alt Symbol |
HsMar1, METNASE, Mar1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SET domain and mariner transposase fusion gene
|
| Other Description |
SET domain and mariner transposase fusion gene-containing protein|SET domain and mariner transposase fusion protein|histone-lysine N-methyltransferase SETMAR
|
| Swissprots |
B4DY74 Q53H47 E7EN68 Q96F41 Q1G668 Q13579
|
| Accessions |
AAC52010 ABC72087 EAW63903 EAW63904 EAW63905 Q53H47 AF054989 AAC09350 AK122967 AK222734 BAD96454 AK297865 BAG60194 AK302296 BAG63636 AK307537 AK311418 AY952295 AAY29570 BC008931 AAH08931 BC011635 AAH11635 BG479260 DC357038 U80776 AAC52012 XM_006713292 XP_006713355 XM_006713293 XP_006713356 XM_006713294 XP_006713357 XM_006713295 XP_006713358 XM_006713296 XP_006713359 XM_011534008 XP_011532310 NM_001243723 NP_001230652 NM_001276325 NP_001263254 NM_006515 NP_006506 NR_075073 NR_024022
|
| Function |
Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18263876}. Chromosome {ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22231448}. Note=Recruited on damaged DNA at sites of double-strand break. {ECO:0000269|PubMed:18263876}.
|
| Tissue Specificity |
Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle. {ECO:0000269|PubMed:16332963}.
|
| Top Pathways |
Lysine degradation
|
