SETMAR

Gene Symbol	SETMAR
Entrez Gene	6419
Alt Symbol	HsMar1, METNASE, Mar1
Species	Human
Gene Type	protein-coding
Description	SET domain and mariner transposase fusion gene
Other Description	SET domain and mariner transposase fusion gene-containing protein|SET domain and mariner transposase fusion protein|histone-lysine N-methyltransferase SETMAR
Swissprots	B4DY74 Q53H47 E7EN68 Q96F41 Q1G668 Q13579
Accessions	AAC52010 ABC72087 EAW63903 EAW63904 EAW63905 Q53H47 AF054989 AAC09350 AK122967 AK222734 BAD96454 AK297865 BAG60194 AK302296 BAG63636 AK307537 AK311418 AY952295 AAY29570 BC008931 AAH08931 BC011635 AAH11635 BG479260 DC357038 U80776 AAC52012 XM_006713292 XP_006713355 XM_006713293 XP_006713356 XM_006713294 XP_006713357 XM_006713295 XP_006713358 XM_006713296 XP_006713359 XM_011534008 XP_011532310 NM_001243723 NP_001230652 NM_001276325 NP_001263254 NM_006515 NP_006506 NR_075073 NR_024022
Function	Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates
Subcellular Location	Nucleus {ECO:0000269|PubMed:18263876}. Chromosome {ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22231448}. Note=Recruited on damaged DNA at sites of double-strand break. {ECO:0000269|PubMed:18263876}.
Tissue Specificity	Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle. {ECO:0000269|PubMed:16332963}.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SETMAR full length protein - ab152672 from Abcam Category Protein Source Wheat germ Species Human

Human SETMAR full length protein - ab125543 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human SETMAR peptide - ab22960 from Abcam Category Peptide Species Human

Human SETMAR protein fragment - ab196433 from Abcam Category Protein Source Mammalian Species Human

SETMAR Antibody Blocking Peptide - LS-E25462 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SETMAR Protein - H00006419-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SETMAR blocking peptide - GTX89887-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

SETMAR Peptide - AC21-0291-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SETMAR - H00006419-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SETMAR - H00006419-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SETMAR Peptide - 46-362P from ProSci Category Peptide Species Human

SETMAR fusion protein - Ag22938 from Proteintech Group Category Protein Species Human

Recombinant SETMAR protein - 31454 from ActiveMotif Category Protein Prices $395.00 Sizes 20 µg Source Baculovirus Species Human

Recombinant Human SETMAR, GST-tagged - SETMAR-6966H from Creative Biomart Category Protein Source Sf9 Cells Species Human

SETMAR protein-GST fusion - 009-001-T30 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

SETMAR protein-GST fusion - 009-001-T30S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human Histone-lysine N-methyltransferase SETMAR(SETMAR) - CSB-YP703613HU CSB-EP703613HU CSB-BP703613HU CSB-MP703613HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SETMAR - TP329337 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SETMAR, Peptide - MBS426809 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Bovine

SETMAR Peptide, Human - M34GP14089H from Creative Peptides Category Peptide Source Synthetic. Species Human

SETMAR Blocking Peptide - CBP5359 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

SETMAR Recombinant Protein Antigen - NBP2-58313PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Histone-lysine N-methyltransferase SETMAR (SETMAR), Recombinant Protein - MBS1403924 from MyBioSource Category Protein Prices $1,475.00, $1,475.00, $1,700.00, $1,700.00, $2,510.00, $2,510.00, $2,950.00, $2,950.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SETMAR, Recombinant Protein - MBS515173 from MyBioSource Category Protein Prices $260.00, $415.00 Sizes 20 µg, 50 µg Source Sf9 insect cells Species Human

SETMAR fusion protein - Ag23011 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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