SETMAR

Gene Symbol	SETMAR
Entrez Gene	6419
Alt Symbol	HsMar1, METNASE, Mar1
Species	Human
Gene Type	protein-coding
Description	SET domain and mariner transposase fusion gene
Other Description	SET domain and mariner transposase fusion gene-containing protein|SET domain and mariner transposase fusion protein|histone-lysine N-methyltransferase SETMAR
Swissprots	B4DY74 Q53H47 E7EN68 Q96F41 Q1G668 Q13579
Accessions	AAC52010 ABC72087 EAW63903 EAW63904 EAW63905 Q53H47 AF054989 AAC09350 AK122967 AK222734 BAD96454 AK297865 BAG60194 AK302296 BAG63636 AK307537 AK311418 AY952295 AAY29570 BC008931 AAH08931 BC011635 AAH11635 BG479260 DC357038 U80776 AAC52012 XM_006713292 XP_006713355 XM_006713293 XP_006713356 XM_006713294 XP_006713357 XM_006713295 XP_006713358 XM_006713296 XP_006713359 XM_011534008 XP_011532310 NM_001243723 NP_001230652 NM_001276325 NP_001263254 NM_006515 NP_006506 NR_075073 NR_024022
Function	Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates
Subcellular Location	Nucleus {ECO:0000269|PubMed:18263876}. Chromosome {ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22231448}. Note=Recruited on damaged DNA at sites of double-strand break. {ECO:0000269|PubMed:18263876}.
Tissue Specificity	Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle. {ECO:0000269|PubMed:16332963}.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SETMAR-cDNA-Clone - DC03148 from Abgent, a WuXi AppTec company Prices $476.55 Sizes 10 µg Species Human Accession BC011635

SETMAR - MBS1266962 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC011635

Human SETMAR cDNA clone(NM_006515.3) - CDFH017330 from Creative Biomart Species Human Accession NM_006515.3

Human SETMAR ORF Clone(NM_006515.3) - CDCR293058 from Creative Biomart Species Human Accession NM_006515.3

Human SETMAR ORF Clone(NM_006515.3) - CDCR293059 from Creative Biomart Species Human Accession NM_006515.3

Human SETMAR ORF Clone(NM_006515.3) - CDCR293060 from Creative Biomart Species Human Accession NM_006515.3

Human SETMAR ORF Clone(NM_006515.3) - CDCR293061 from Creative Biomart Species Human Accession NM_006515.3

human SETMAR ORF clone - CDCH079082 from Creative Biomart Species Human Accession NM_001243723

human SETMAR ORF clone - CDCH079083 from Creative Biomart Species Human Accession NM_001243723

human SETMAR ORF clone - CDCH079084 from Creative Biomart Species Human Accession NM_001243723

human SETMAR ORF clone - CDCH079085 from Creative Biomart Species Human Accession NM_001243723

human SETMAR ORF clone - CDCH079086 from Creative Biomart Species Human Accession NM_001243723

human SETMAR ORF clone - CDCH079087 from Creative Biomart Species Human Accession NM_001243723

human SETMAR ORF clone - CDCH079088 from Creative Biomart Species Human Accession NM_001243723

human SETMAR ORF clone - CDCH079089 from Creative Biomart Species Human Accession NM_001243723

Human SETMAR Gene ORF cDNA clone in cloning vector - HG12237-G from Sino Biological Species Human

Human SETMAR Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12237-NF from Sino Biological Species Human

Human SETMAR Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12237-NM from Sino Biological Species Human

Human SETMAR Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12237-CF from Sino Biological Species Human

Human SETMAR Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12237-CM from Sino Biological Species Human

Human SETMAR Gene ORF cDNA clone expression plasmid, C-HA tag - HG12237-CY from Sino Biological Species Human

Human SETMAR Gene ORF cDNA clone expression plasmid, N-HA tag - HG12237-NY from Sino Biological Species Human

Human SETMAR Gene ORF cDNA clone expression plasmid, N-His tag - HG12237-NH from Sino Biological Species Human

Human SETMAR Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG12237-ANG from Sino Biological Species Human

Human SETMAR Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12237-ACG from Sino Biological Species Human

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