DOCK3

Gene Symbol	DOCK3
Entrez Gene	1795
Alt Symbol	MOCA, PBP
Species	Human
Gene Type	protein-coding
Description	dedicator of cytokinesis 3
Other Description	dedicator of cytokinesis protein 3|modifier of cell adhesion|presenilin-binding protein
Swissprots	Q8IZD9 O15017
Accessions	CCQ43290 EAW65134 EAW65135 EAW65136 EAW65137 Q8IZD9 AB002297 BAA20759 AK310984 AY145303 AAN12301 AY254099 AAP80572 BC037933 BC045793 BC131746 AAI31747 BC156339 AAI56340 BC157127 AAI57128 XM_005264914 XP_005264971 XM_005264915 XP_005264972 XM_005264916 XP_005264973 XM_005264917 XP_005264974 XM_005264918 XP_005264975 XM_006713008 XP_006713071 XM_006713009 XP_006713072 XM_006713010 XP_006713073 XM_011533441 XP_011531743 XM_011533442 XP_011531744 XM_011533443 XP_011531745 XM_011533444 XP_011531746 XM_011533445 XP_011531747 XM_011533446 XP_011531748 NM_004947 NP_004938
Function	Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles. {ECO:0000269|PubMed:11696419}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MOCA (C-16) - sc-70182 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MOCA (T-20) - sc-70185 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MOCA (S-20) - sc-70184 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MOCA (H-93) - sc-135232 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-DOCK3 antibody - ab75911 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DOCK3 Antibody - LS-C335377 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

DOCK3 Antibody - AF7134 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

DOCK3 Antibody - NBP1-93647 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DOCK3 Polyclonal Antibody - bs-11657R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11657R-A350 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11657R-A488 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11657R-A555 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11657R-A647 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, Cy3 Conjugated - bs-11657R-Cy3 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, Cy5 Conjugated - bs-11657R-Cy5 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, Cy5.5 Conjugated - bs-11657R-Cy5.5 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, Cy7 Conjugated - bs-11657R-Cy7 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, FITC Conjugated - bs-11657R-FITC from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, Biotin Conjugated - bs-11657R-Biotin from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-DOCK3 Polyclonal Antibody, HRP Conjugated - bs-11657R-HRP from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DOCK3 antibody produced in rabbit - HPA037544 from Sigma-Aldrich Host Rabbit Clonality Polyclonal

CSEN antibody [N1C3] - GTX105901 from GeneTex Prices $119.00 Sizes 25 μl Host Rabbit Clonality Polyclonal

CSEN antibody [N1C3-2] - GTX111911 from GeneTex Host Rabbit Clonality Polyclonal

Human DOCK3 Antibody - AF7134 from R&D Systems Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep

Human DOCK3 Affinity Purified Polyclonal Ab, Sheep IgG - AF7134-SP from R&D Systems Host Sheep Clonality Polyclonal

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